{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:36:49Z","timestamp":1791275809818,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":510,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol Clin Exp Res"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1111\/acer.12395","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T15:04:04Z","timestamp":1397055844000},"page":"1671-1679","source":"Crossref","is-referenced-by-count":34,"title":["Effects of Prenatal Alcohol Exposure on Testosterone and Pubertal Development"],"prefix":"10.1111","volume":"38","author":[{"given":"R. Colin","family":"Carter","sequence":"first","affiliation":[{"name":"Division of Pediatric Emergency Medicine ; Columbia University Medical Center; New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine; Detroit Michigan"},{"name":"Departments of Human Biology and of Psychiatry and Mental Health, University of Cape Town Faculty of Health Sciences; Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil C.","family":"Dodge","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine; Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Granger","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Salivary Bioscience Research ; Arizona State University; Tempe Arizona"},{"name":"Johns Hopkins University School of Medicine, School of Nursing, and Bloomberg School of Public Health ; Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra W.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine; Detroit Michigan"},{"name":"Departments of Human Biology and of Psychiatry and Mental Health, University of Cape Town Faculty of Health Sciences; Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"10.1111\/acer.12395-BIB0001|acer12395-cit-0001","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1067\/S0022-3476(03)00442-6","article-title":"Validation of a new biomarker of fetal exposure to alcohol","volume":"143","author":"Bearer","year":"2003","journal-title":"J Pediatr"},{"key":"10.1111\/acer.12395-BIB0002|acer12395-cit-0002","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1210\/en.2007-1796","article-title":"Neonatal gonadectomy and adult testosterone replacement suggest an involvement of limbic arginine vasopressin and androgen receptors in the organization of the hypothalamic-pituitary-adrenal axis","volume":"149","author":"Bingham","year":"2008","journal-title":"Endocrinology"},{"key":"10.1111\/acer.12395-BIB0003|acer12395-cit-0003","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.15288\/jsa.1975.36.1154","article-title":"Measurement and interpretation of drinking behavior. I. On measuring patterns of alcohol consumption. II. Relationships between drinking behavior and social adjustment in a sample of problem drinkers","volume":"36","author":"Bowman","year":"1975","journal-title":"J Stud Alcohol"},{"key":"10.1111\/acer.12395-BIB0004|acer12395-cit-0004","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1530-0277.2012.01940.x","article-title":"Fetal alcohol-related growth restriction from birth through young adulthood and moderating effects of maternal prepregnancy weight","volume":"37","author":"Carter","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0005|acer12395-cit-0005","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1530-0277.2002.tb02459.x","article-title":"Prenatal alcohol exposure predicts continued deficits in offspring size at 14\u00a0years of age","volume":"26","author":"Day","year":"2002","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB1005|acer12395-cit-1005","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1111\/j.1530-0277.2012.01819.x","article-title":"Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero","volume":"36","author":"Eckstrand","year":"2002","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0006|acer12395-cit-0006","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0039-128X(92)90032-5","article-title":"Racial\/ethnic variations in male testosterone levels: a probable contributor to group differences in health","volume":"57","author":"Ellis","year":"1992","journal-title":"Steroids"},{"key":"10.1111\/acer.12395-BIB0007|acer12395-cit-0007","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1159\/000124690","article-title":"Effect of prenatal alcohol exposure on sexual maturation of female rat offspring","volume":"44","author":"Esquifino","year":"1986","journal-title":"Neuroendocrinology"},{"key":"10.1111\/acer.12395-BIB0008|acer12395-cit-0008","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/hbeh.1998.1492","article-title":"Salivary testosterone determination in studies of child health and development","volume":"35","author":"Granger","year":"1999","journal-title":"Horm Behav"},{"key":"10.1111\/acer.12395-BIB0009|acer12395-cit-0009","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.psyneuen.2004.02.005","article-title":"The \u201ctrouble\u201d with salivary testosterone","volume":"29","author":"Granger","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"10.1111\/acer.12395-BIB0010|acer12395-cit-0010","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/0024-3205(85)90295-4","article-title":"Exposure to alcohol in utero alters the adult patterns of luteinizing hormone secretion in male and female rats","volume":"37","author":"Handa","year":"1985","journal-title":"Life Sci"},{"key":"10.1111\/acer.12395-BIB0011|acer12395-cit-0011","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.neubiorev.2009.06.004","article-title":"Prenatal alcohol exposure: fetal programming and later life vulnerability to stress, depression and anxiety disorders","volume":"34","author":"Hellemans","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1111\/acer.12395-BIB0012|acer12395-cit-0012","doi-asserted-by":"crossref","first-page":"e1058","DOI":"10.1542\/peds.2011-3291","article-title":"Secondary sexual characteristics in boys: data from the pediatric research in office settings network","volume":"130","author":"Herman-Giddens","year":"2012","journal-title":"Pediatrics"},{"key":"10.1111\/acer.12395-BIB0013|acer12395-cit-0013","first-page":"21","volume-title":"Four factor index of social status","volume":"8","author":"Hollingshead","year":"2011"},{"key":"10.1111\/acer.12395-BIB0014|acer12395-cit-0014","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0022-3999(67)90010-4","article-title":"The social readjustment rating scale","volume":"11","author":"Holmes","year":"1967","journal-title":"J Psychosom Res"},{"key":"10.1111\/acer.12395-BIB0018|acer12395-cit-0018","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1530-0277.1993.tb00744.x","article-title":"Teratogenic effects of alcohol on infant development","volume":"17","author":"Jacobson","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0015|acer12395-cit-0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0954579499002011","article-title":"Effects of prenatal alcohol and cocaine exposure on infant cortisol levels","volume":"11","author":"Jacobson","year":"1999","journal-title":"Dev Psychopathol"},{"key":"10.1111\/acer.12395-BIB0016|acer12395-cit-0016","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1542\/peds.109.5.815","article-title":"Validity of maternal report of prenatal alcohol, cocaine, and smoking in relation to neurobehavioral outcome","volume":"109","author":"Jacobson","year":"2002","journal-title":"Pediatrics"},{"key":"10.1111\/acer.12395-BIB0017|acer12395-cit-0017","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1097\/01.ALC.0000145691.81233.FA","article-title":"Maternal age, alcohol abuse history, and quality of parenting as moderators of the effects of prenatal alcohol exposure on 7.5-year intellectual function","volume":"28","author":"Jacobson","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0019|acer12395-cit-0019","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0741-8329(90)90063-I","article-title":"Inhibition of testicular steroidogenesis in the neonatal rat following acute ethanol exposure","volume":"7","author":"Kelce","year":"1990","journal-title":"Alcohol"},{"key":"10.1111\/acer.12395-BIB0020|acer12395-cit-0020","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1373\/clinchem.2013.204123","article-title":"Complex biological pattern of fertility hormones in children and adolescents: a study of children form the CALIPER cohort and establishment of pediatric reference intervals","volume":"59","author":"Konforte","year":"2013","journal-title":"Clin Chem"},{"key":"10.1111\/acer.12395-BIB0021|acer12395-cit-0021","first-page":"1","article-title":"2000 CDC Growth Charts for the United States: methods and development","volume":"246","author":"Kuczmarski","year":"2002","journal-title":"Vital Health Stat 11"},{"key":"10.1111\/acer.12395-BIB0022|acer12395-cit-0022","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.psyneuen.2009.04.001","article-title":"Role of testosterone in mediating prenatal ethanol effects on hypothalamic-pituitary-adrenal activity in male rats","volume":"34","author":"Lan","year":"2009a","journal-title":"Psychoneuroendocrinology"},{"key":"10.1111\/acer.12395-BIB0023|acer12395-cit-0023","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2826.2006.01462.x","article-title":"Prenatal ethanol exposure alters the effects of gonadectomy on hypothalamic-pituitary-adrenal activity in male rats","volume":"18","author":"Lan","year":"2006","journal-title":"J Neuroendocrinol"},{"key":"10.1111\/acer.12395-BIB0024|acer12395-cit-0024","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1530-0277.2009.00929.x","article-title":"Effects of prenatal ethanol exposure on hypothalamic-pituitary-adrenal function across the estrous cycle","volume":"33","author":"Lan","year":"2009b","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0025|acer12395-cit-0025","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","volume":"44","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"10.1111\/acer.12395-BIB0026|acer12395-cit-0026","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/adc.45.239.13","article-title":"Variations in the pattern of pubertal changes in boys","volume":"45","author":"Marshall","year":"1970","journal-title":"Arch Dis Child"},{"key":"10.1111\/acer.12395-BIB0027|acer12395-cit-0027","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/07420520701649471","article-title":"Diurnal and seasonal cortisol, testosterone, and DHEA rhythms in boys and girls during puberty","volume":"24","author":"Matchock","year":"2007","journal-title":"Chronobiol Int"},{"key":"10.1111\/acer.12395-BIB0028|acer12395-cit-0028","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1126\/science.6719121","article-title":"Prenatal alcohol exposure alters adult expression of sexually dimorphic behavior in the rat","volume":"224","author":"McGivern","year":"1984","journal-title":"Science"},{"key":"10.1111\/acer.12395-BIB0030|acer12395-cit-0030","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1530-0277.1993.tb05232.x","article-title":"Decreased postnatal testosterone surge in male rats exposed to ethanol during the last week of gestation","volume":"17","author":"McGivern","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0031|acer12395-cit-0031","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1530-0277.1995.tb01526.x","article-title":"Loss of reproductive competence at an earlier age in female rats exposed prenatally to ethanol","volume":"19","author":"McGivern","year":"1995","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0032|acer12395-cit-0032","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1530-0277.1988.tb00188.x","article-title":"Lack of prenatal testosterone surge in fetal rats exposed to alcohol: alterations in testicular morphology and physiology","volume":"12","author":"McGivern","year":"1988","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0033|acer12395-cit-0033","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0741-8329(92)90077-N","article-title":"Delayed onset of puberty and subtle alterations in GnRH neuronal morphology in female rats exposed prenatally to ethanol","volume":"9","author":"McGivern","year":"1992","journal-title":"Alcohol"},{"key":"10.1111\/acer.12395-BIB0034|acer12395-cit-0034","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1530-0277.2009.01137.x","article-title":"Prenatal alcohol exposure alters biobehavioral reactivity to pain in newborns","volume":"34","author":"Oberlander","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0035|acer12395-cit-0035","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev.ps.39.020188.003055","article-title":"Adolescent development","volume":"39","author":"Petersen","year":"1988","journal-title":"Annu Rev Psychol"},{"key":"10.1111\/acer.12395-BIB0036|acer12395-cit-0036","first-page":"45","article-title":"Serum testosterone levels in healthy young black and white men","volume":"76","author":"Ross","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"10.1111\/acer.12395-BIB0037|acer12395-cit-0037","volume-title":"Salivary Testosterone Enzyme Immunoassay Kit (Rev. 2012)","author":"Salimetrics","year":"2012"},{"key":"10.1111\/acer.12395-BIB0038|acer12395-cit-0038","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1467-8624.2004.00656.x","article-title":"Moderate level alcohol during pregnancy, prenatal stress, or both and limbic-hypothalamic-pituitary-adrenocortical axis response to stress in rhesus monkeys","volume":"75","author":"Schneider","year":"2004","journal-title":"Child Dev"},{"key":"10.1111\/acer.12395-BIB0039|acer12395-cit-0039","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/jama.1991.03460150065025","article-title":"Fetal alcohol syndrome in adolescents and adults","volume":"265","author":"Streissguth","year":"1991","journal-title":"JAMA"},{"key":"10.1111\/acer.12395-BIB0040|acer12395-cit-0040","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1001\/archpediatrics.2009.261","article-title":"Eunice Kennedy Shriver NICHD Early Child Care Research Network","volume":"164","author":"Susman","year":"2010","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1111\/acer.12395-BIB0041|acer12395-cit-0041","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1530-0277.1985.tb05559.x","article-title":"Effects of in utero exposure to alcohol upon male rats","volume":"9","author":"Udani","year":"1985","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12395-BIB0042|acer12395-cit-0042","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","article-title":"Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome","volume":"20","author":"Weinberg","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"10.1111\/acer.12395-BIB0043|acer12395-cit-0043","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0741-8329(97)00037-2","article-title":"Gonadotropin secretion in infantile rats exposed to ethanol in utero","volume":"14","author":"Wilson","year":"1997","journal-title":"Alcohol"},{"key":"10.1111\/acer.12395-BIB1044|acer12395-cit-1044","article-title":"Statistical Principles in Experimental Design","author":"Winer","year":"1971","journal-title":"2nd ed"},{"key":"10.1111\/acer.12395-BIB0044|acer12395-cit-0044","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/j.1467-8624.2008.01224.x","article-title":"Fetal substance exposure and cumulative environmental risk in an African American cohort","volume":"79","author":"Yumoto","year":"2008","journal-title":"Child Dev"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.12395","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/acer.12395\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T16:55:16Z","timestamp":1625504116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.12395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,9]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"URL":"https:\/\/doi.org\/10.1111\/acer.12395","relation":{},"ISSN":["0145-6008"],"issn-type":[{"value":"0145-6008","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4,9]]}}}