{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:23:57Z","timestamp":1790843037281,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":431,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"NIH","award":["AA016379"],"award-info":[{"award-number":["AA016379"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol Clin Exp Res"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1111\/acer.12445","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T20:14:56Z","timestamp":1403900096000},"page":"2113-2118","source":"Crossref","is-referenced-by-count":48,"title":["A Randomized, Double-Blind, Placebo-Controlled Trial of Quetiapine in Patients with Bipolar Disorder, Mixed or Depressed Phase, and Alcohol Dependence"],"prefix":"10.1111","volume":"38","author":[{"given":"E. Sherwood","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Davila","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Carmody","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. John","family":"Rush","sequence":"additional","affiliation":[{"name":"Duke-NUS; Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryon","family":"Adinoff","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"},{"name":"Dallas Veterans Affairs Medical Center; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Caetano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"},{"name":"School of Health Professions; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Swann","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences; Baylor College of Medicine; Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabha","family":"Sunderajan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Bret","sequence":"additional","affiliation":[{"name":"Department of Psychiatry; The University of Texas Southwestern Medical Center; Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"10.1111\/acer.12445-BIB0001|acer12445-cit-0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0165-0327(90)90077-L","article-title":"Predictors of outcome in prophylactic lithium treatment: a 2-year prospective study","volume":"18","author":"Aagaard","year":"1990","journal-title":"J Affect Disord"},{"key":"10.1111\/acer.12445-BIB0002|acer12445-cit-0002","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1192\/bjp.154.5.672","article-title":"A rating scale for drug-induced akathisia","volume":"154","author":"Barnes","year":"1989","journal-title":"Br J Psychiatry"},{"key":"10.1111\/acer.12445-BIB0003|acer12445-cit-0003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-0327(01)00440-2","article-title":"Principles of effectiveness trials and their implementation in VA Cooperative Study #430: \u2018reducing the efficacy-effectiveness gap in bipolar disorder\u2019","volume":"67","author":"Bauer","year":"2001","journal-title":"J Affect Disord"},{"key":"10.1111\/acer.12445-BIB0004|acer12445-cit-0004","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1111\/j.1530-0277.2009.01024.x","article-title":"A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence","volume":"33","author":"Brown","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12445-BIB0005|acer12445-cit-0005","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4088\/JCP.v69n0502","article-title":"A randomized, double-blind, placebo-controlled add-on trial of quetiapine in outpatients with bipolar disorder and alcohol use disorders","volume":"69","author":"Brown","year":"2008","journal-title":"J Clin Psychiatry"},{"key":"10.1111\/acer.12445-BIB0006|acer12445-cit-0006","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1034\/j.1399-5618.2003.00017.x","article-title":"Suicide risk in bipolar patients: the role of co-morbid substance use disorders","volume":"5","author":"Dalton","year":"2003","journal-title":"Bipolar Disord"},{"key":"10.1111\/acer.12445-BIB0007|acer12445-cit-0007","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders","author":"First","year":"1995"},{"key":"10.1111\/acer.12445-BIB0008|acer12445-cit-0008","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1530-0277.1999.tb04349.x","article-title":"Psychometric properties of the Penn Alcohol Craving Scale","volume":"23","author":"Flannery","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12445-BIB0009|acer12445-cit-0009","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1192\/bjp.bp.107.048504","article-title":"Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials","volume":"194","author":"Geddes","year":"2009","journal-title":"Br J Psychiatry"},{"key":"10.1111\/acer.12445-BIB0010|acer12445-cit-0010","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(13)60857-0","article-title":"Treatment of bipolar disorder","volume":"381","author":"Geddes","year":"2013","journal-title":"Lancet"},{"key":"10.1111\/acer.12445-BIB0011|acer12445-cit-0011","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.addbeh.2010.11.006","article-title":"A double-blind, placebo-controlled, randomized pilot study comparing quetiapine with placebo, associated to naltrexone, in the treatment of alcohol-dependent patients","volume":"36","author":"Guardia","year":"2011","journal-title":"Addict Behav"},{"key":"10.1111\/acer.12445-BIB0012|acer12445-cit-0012","first-page":"534","volume-title":"ECDEU Assessment Manual for Psychopharmacology: Revised (DHEW publication number ADM 76-338)","author":"Guy","year":"1976"},{"key":"10.1111\/acer.12445-BIB0013|acer12445-cit-0013","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1111\/acer.12445-BIB0014|acer12445-cit-0014","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/JCP.0b013e3180ca86e5","article-title":"A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism","volume":"27","author":"Kampman","year":"2007","journal-title":"J Clin Psychopharmacol"},{"key":"10.1111\/acer.12445-BIB0015|acer12445-cit-0015","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1111\/acer.12445-BIB0016|acer12445-cit-0016","first-page":"556","article-title":"Defining subgroups of dual diagnosis patients for service planning","volume":"45","author":"Lehman","year":"1994","journal-title":"Hosp Community Psychiatry"},{"key":"10.1111\/acer.12445-BIB0017|acer12445-cit-0017","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1530-0277.2011.01649.x","article-title":"A double-blind, placebo-controlled trial to assess the efficacy of quetiapine fumarate XR in very heavy-drinking alcohol-dependent patients","volume":"36","author":"Litten","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12445-BIB0018|acer12445-cit-0018","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00005053-198001000-00006","article-title":"An improved diagnostic evaluation instrument for substance abuse patients. The Addiction Severity Index","volume":"168","author":"McLellan","year":"1980","journal-title":"J Nerv Ment Dis"},{"issue":"5 Pt 1","key":"10.1111\/acer.12445-BIB0019|acer12445-cit-0019","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1399-5618.2006.00350.x","article-title":"Placebo-level incidence of extrapyramidal symptoms (EPS) with quetiapine in controlled studies of patients with bipolar mania","volume":"8","author":"Nasrallah","year":"2006","journal-title":"Bipolar Disord"},{"key":"10.1111\/acer.12445-BIB0020|acer12445-cit-0020","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1001\/jama.1990.03450190043026","article-title":"Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study","volume":"264","author":"Regier","year":"1990","journal-title":"JAMA"},{"key":"10.1111\/acer.12445-BIB0200|acer12445-cit-0200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1017\/S0033291700035558","article-title":"The Inventory of Depressive Symptomatology (IDS): psychometric properties","volume":"26","author":"Rush","year":"1996","journal-title":"Psychol Med"},{"key":"10.1111\/acer.12445-BIB0022|acer12445-cit-0022","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/archpsyc.62.1.37","article-title":"Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study","volume":"62","author":"Salloum","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1111\/acer.12445-BIB0023|acer12445-cit-0023","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2165\/11203840-000000000-00000","article-title":"Quetiapine: a review of its use in the management of bipolar depression","volume":"26","author":"Sanford","year":"2012","journal-title":"CNS Drugs"},{"key":"10.1111\/acer.12445-BIB0024|acer12445-cit-0024","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00132576-200205000-00004","article-title":"Cognitive-behavioral treatment of bipolar disorder and substance abuse: a preliminary randomized study","volume":"1","author":"Schmitz","year":"2002","journal-title":"Addict Disord Their Treat"},{"key":"10.1111\/acer.12445-BIB0025|acer12445-cit-0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0447.1970.tb02066.x","article-title":"A rating scale for extrapyramidal side effects","volume":"212","author":"Simpson","year":"1970","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"10.1111\/acer.12445-BIB0026|acer12445-cit-0026","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1399-5618.2004.00173.x","article-title":"Quality of life and its correlates in patients with dual diagnosis of bipolar affective disorder and substance dependence","volume":"7","author":"Singh","year":"2005","journal-title":"Bipolar Disord"},{"key":"10.1111\/acer.12445-BIB0027|acer12445-cit-0027","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4612-0357-5_3","volume-title":"Measuring Alcohol Consumption: Psychosocial and Biological Methods","author":"Sobell","year":"1992"},{"key":"10.1111\/acer.12445-BIB0028|acer12445-cit-0028","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00005053-199406000-00007","article-title":"Substance abuse and bipolar affective disorder","volume":"182","author":"Sonne","year":"1994","journal-title":"J Nerv Ment Dis"},{"key":"10.1111\/acer.12445-BIB0029|acer12445-cit-0029","doi-asserted-by":"crossref","first-page":"e1001403","DOI":"10.1371\/journal.pmed.1001403","article-title":"Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes","volume":"10","author":"Spielmans","year":"2013","journal-title":"PLoS Med"},{"key":"10.1111\/acer.12445-BIB0030|acer12445-cit-0030","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1111\/j.1530-0277.2010.01270.x","article-title":"A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence","volume":"34","author":"Stedman","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1111\/acer.12445-BIB0031|acer12445-cit-0031","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/j.1360-0443.1989.tb00737.x","article-title":"Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar)","volume":"84","author":"Sullivan","year":"1989","journal-title":"Br J Addict"},{"key":"10.1111\/acer.12445-BIB0032|acer12445-cit-0032","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archpsyc.1996.01830090023004","article-title":"A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia","volume":"53","author":"Thase","year":"1996","journal-title":"Arch Gen Psychiatry"},{"key":"10.1111\/acer.12445-BIB0033|acer12445-cit-0033","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A rating scale for mania: reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br J Psychiatry"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.12445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.12445","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/acer.12445\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T17:22:30Z","timestamp":1625505750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.12445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,27]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"URL":"https:\/\/doi.org\/10.1111\/acer.12445","archive":["Portico"],"relation":{},"ISSN":["0145-6008"],"issn-type":[{"value":"0145-6008","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6,27]]}}}