{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:20:52Z","timestamp":1787563252723,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health Grant","doi-asserted-by":"crossref","award":["5K08 HL AA017622"],"award-info":[{"award-number":["5K08 HL AA017622"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp; Exp Res"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n Background<\/jats:title>\n \n Dysregulated adipose tissue metabolism has been implicated in the pathogenesis of alcoholic liver disease in murine models. We aimed to characterize serum markers of adipose tissue metabolism and inflammation in patients with severe acute alcoholic hepatitis (\n AAH<\/jats:styled-content>\n ) and determine their utility to predict survival in severe\n AAH<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A prospective, case\u2013control study design was used. Seventy\u2010six patients hospitalized with severe\n AAH<\/jats:styled-content>\n and 25 ambulatory patients with alcoholic cirrhosis as controls were included. Serum samples were collected for biochemical analyses. Patients were followed for 180\u00a0days after enrollment to determine the survival.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n AAH<\/jats:styled-content>\n patients exhibited higher serum glycerol and free fatty acid levels, suggesting enhanced adipose tissue triglyceride hydrolysis. Patients with\n AAH<\/jats:styled-content>\n demonstrated a distinct serum lipidomic profile compared with alcoholic cirrhosis but not in systemic and adipose\u2010specific insulin resistance.\n AAH<\/jats:styled-content>\n patients had higher serum resistin and plasmin activation inhibitor\u20101 levels, while serum leptin was decreased. Serum levels of the prolipolytic cytokines tumor necrosis factor\u2010\n \u03b1<\/jats:italic>\n (\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n ), interleukin (\n IL<\/jats:styled-content>\n )\u20106,\n IL<\/jats:styled-content>\n \u20108, and\n IL<\/jats:styled-content>\n \u201015 were significantly higher in\n AAH<\/jats:styled-content>\n patients. Only 53% of\n AAH<\/jats:styled-content>\n patients survived 180\u00a0days after admission, while all cirrhotic patients were alive at the end of the study period. Among patients with severe\n AAH<\/jats:styled-content>\n , white blood cell count, hemoglobin, resistin,\n IL<\/jats:styled-content>\n \u20106 and\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n were associated with 180\u2010day survival, and all 5 markers demonstrated accuracy by area under receiver\u2013operator curve analysis. Serum\n IL<\/jats:styled-content>\n \u20106 levels \u226538.66\u00a0pg\/ml most precisely identified deaths in severe\n AAH<\/jats:styled-content>\n . Patients with\n IL<\/jats:styled-content>\n \u20106\u00a0\u2265\u00a038.66\u00a0pg\/ml had significantly decreased mean survival compared to those with lower levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n AAH<\/jats:styled-content>\n patients demonstrate evidence of increased adipose tissue lipolysis and altered serum lipidomic profile compared with alcoholic cirrhosis patients.\n IL<\/jats:styled-content>\n \u20106 may be a useful biomarker to risk stratify severe\n AAH<\/jats:styled-content>\n patients at the highest risk of mortality.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/acer.12558","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T10:41:43Z","timestamp":1416825703000},"page":"2712-2721","source":"Crossref","is-referenced-by-count":38,"title":["Stratification of Risk of Death in Severe Acute Alcoholic Hepatitis Using a Panel of Adipokines and Cytokines"],"prefix":"10.1111","volume":"38","author":[{"given":"Vikrant","family":"Rachakonda","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Gabbert","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Raina","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanan","family":"Li","sequence":"additional","affiliation":[{"name":"Division 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