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However, it is not fully understood how forebrain activity is altered in <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>+ individuals, and ultimately how these alterations may contribute to substance use disorder risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we tested 72 <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>+ and 32 <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\u2212 youths performing a go\/no\u2010go task and examined activations in blocks with only go trials (Go Only), blocks with 50% go and 50% no\u2010go trials (Go\/NoGo), and a contrast of those 2 blocks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>+ youths had significantly greater cerebral activations in both the Go and Go\/NoGo blocks than <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>\u2212 youths in regions including the posterior cingulate\/precuneus, bilateral middle\/superior temporal gyrus, and medial superior frontal gyrus with no significant group differences in the subtraction between Go Only and Go\/NoGo blocks. Additionally, <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>+ youths had moderately slower reaction times on go trials in the Go Only blocks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that global activation increase in <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>+ youths are modulated by <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content> density and are not specific to the inhibitory components of the task. This pattern of increased activations in <jats:styled-content style=\"fixed-case\">FH<\/jats:styled-content>+ youths may be at least partially due to impaired forebrain white matter development leading to greater activations\/less efficient neural communication during task performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12571","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T20:44:41Z","timestamp":1416343481000},"page":"2944-2951","source":"Crossref","is-referenced-by-count":25,"title":["Increased Forebrain Activations in Youths with Family Histories of Alcohol and Other Substance Use Disorders Performing a Go\/NoGo Task"],"prefix":"10.1111","volume":"38","author":[{"given":"Ashley","family":"Acheson","sequence":"first","affiliation":[{"name":"Research Imaging Institute University of Texas Health Science Center at San Antonio San Antonio Texas"},{"name":"Department of Psychiatry University of Texas Health Science Center at San Antonio San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malle A.","family":"Tagamets","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Maryland Psychiatric Research Center University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Rowland","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Maryland Psychiatric Research Center University of Maryland School of Medicine Baltimore Maryland"},{"name":"Russell H. 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