{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:22:31Z","timestamp":1790616151692,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA030354"],"award-info":[{"award-number":["R01 DA030354"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R03 DA027457"],"award-info":[{"award-number":["R03 DA027457"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alcohol dependence (AD) has global effects on brain structure and function, including frontolimbic regions regulating affective processing. Preliminary evidence suggests alcohol blunts limbic response to negative affective stimuli and increases activation to positive affective stimuli. Subtle gender differences are also evident during affective processing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen abstinent AD individuals (8 F, 6 M) and 14 healthy controls (9 F, 5 M), ages 23 to 60, were included in this facial affective processing functional magnetic resonance imaging pilot study. Whole\u2010brain linear regression analyses were performed, and follow\u2010up analyses examined whether AD status significantly predicted depressive symptoms and\/or coping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fearful Condition\u2014The AD group demonstrated reduced activation in the right medial frontal gyrus, compared with controls. Gender moderated the effects of AD in bilateral inferior frontal gyri. Happy Condition\u2014AD individuals had increased activation in the right thalamus. Gender moderated the effects of AD in the left caudate, right middle frontal gyrus, left paracentral lobule, and right lingual gyrus. Interactive AD and gender effects for fearful and happy faces were such that AD men activated more than control men, but AD women activated less than control women. Enhanced coping was associated with greater activation in right medial frontal gyrus during fearful condition in AD individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Abnormal affective processing in AD may be a marker of alcoholism risk or a consequence of chronic alcoholism. Subtle gender differences were observed, and gender moderated the effects of AD on neural substrates of affective processing. AD individuals with enhanced coping had brain activation patterns more similar to controls. Results help elucidate the effects of alcohol, gender, and their interaction on affective processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.12626","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T01:18:57Z","timestamp":1423876737000},"page":"272-281","source":"Crossref","is-referenced-by-count":21,"title":["Gender Effects in Alcohol Dependence: An fMRI Pilot Study Examining Affective Processing"],"prefix":"10.1111","volume":"39","author":[{"given":"Claudia B.","family":"Padula","sequence":"first","affiliation":[{"name":"Department of Psychiatry Veterans Affairs Palo Alto Health Care System Palo Alto California"},{"name":"Department of Psychiatry and Behavioral Sciences Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Anthenelli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Veterans Affairs San Diego Healthcare System and University of California San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Eliassen","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Lisdahl","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Wisconsin\u2010Milwaukee Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"American Psychiatric Association(1994)Diagnostic and Statistical Manual of Mental Disorders 4th edn.American Psychiatric Association Washington DC."},{"key":"e_1_2_6_3_1","unstructured":"AnthenelliRM BlomTJ HeffnerJL JohnsonCS WandGS(2009)Sex differences in the cortisol response to citalopram stimulation in abstinent alcohol dependent and control women and men. Poster presented at the 32nd Annual RSA Scientific Conference San Diego CA June 20\u201324."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2008.03.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1463-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108089604"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.074"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2006.00043.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4862-03.2004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1014::AID-MRM4>3.0.CO;2-F"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01514.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.09.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.02.009"},{"key":"e_1_2_6_16_1","unstructured":"MB First M Gibbon RL Spitzer JBW Williams LS Benjamin 1997 American Psychiatric Press Inc. Washington DC"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00321.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136617"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.50.3.571"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0086-08.2008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014418503754"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00006-7"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/1528-3542.4.2.201"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3282f0d40c"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00406.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1985.01790340028004"},{"key":"e_1_2_6_28_1","first-page":"181","article-title":"Male and female sensitivity to alcohol\u2010induced brain damage","volume":"27","author":"Hommer DW","year":"2003","journal-title":"Alcohol Res Health"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32832c5f4d"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009395"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.12.048"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00002-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.11.048"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.070"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.06.017"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.01.018"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000164376.69978.6B"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1992.tb00698.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01026.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00602.x"},{"key":"e_1_2_6_41_1","first-page":"211","article-title":"Genetic influences in emotion dysfunction and alcoholism\u2010related brain damage","volume":"1","author":"Oscar\u2010Berman M","year":"2005","journal-title":"Neuropsychiatr Dis Treat"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agr066"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2010.06.038"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1041309"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01197.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1087"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00447.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328305b722"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-0357-5_3"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450600934432"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.2.238"},{"key":"e_1_2_6_52_1","unstructured":"J Talairach P Tournoux 1988 Thieme New York NY"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70893-1"},{"key":"e_1_2_6_54_1","unstructured":"BD Ward 2000 Biophysics Research Institute Medical College of Wisconsin Milwaukee WI"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.12626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.12626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T08:15:23Z","timestamp":1695456923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.12626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/acer.12626"],"URL":"https:\/\/doi.org\/10.1111\/acer.12626","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}