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Analyses were conducted by structural modeling, examining within\u2010pair differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The best\u2010fitting model explained 73% of the variance in men and 71% in women for last year<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>. Forty\u2010nine percent of paths differed significantly across sexes. Ten variables had appreciably different predictive effects on<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>in males versus females. Three were stronger in females: familial risk, early\u2010onset anxiety disorders, and nicotine dependence. Seven predictors had a stronger total effect in males: novelty seeking, conduct disorder, childhood sexual abuse, parental loss, neuroticism, low self\u2010esteem, and low marital satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a co\u2010twin control design, which matches sisters and brothers on genetic and familial\u2013environmental background, we found numerous sex differences in predictors of last year<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>. Factors that were more prominent in men and in women were diverse, reflecting both internalizing and externalizing psychopathology. The model was slightly more successful at predicting<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>in men than in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12694","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T13:39:17Z","timestamp":1428327557000},"page":"998-1007","source":"Crossref","is-referenced-by-count":29,"title":["Sex Differences in the Pathways to Symptoms of Alcohol Use Disorder: A Study of Opposite\u2010Sex Twin Pairs"],"prefix":"10.1111","volume":"39","author":[{"given":"Kenneth S.","family":"Kendler","sequence":"first","affiliation":[{"name":"Department of Psychiatry Virginia Commonwealth University School of Medicine Richmond Virginia"},{"name":"Department of Human and Molecular Genetics Virginia Commonwealth University School of Medicine Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis 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