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No pharmacologic interventions have been found to decrease both alcohol use and\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      symptom severity relative to matched placebo. Prazosin, an alpha\u20101 adrenoreceptor antagonist, has demonstrated the efficacy of reducing\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      symptoms among individuals with one or the other disorder and may be useful in addressing comorbid\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prazosin and matched placebo were compared in the context of an outpatient 6\u2010week double\u2010blind randomized controlled pilot trial involving 30 individuals with comorbid\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      . Medication was titrated to 4\u00a0mg\u00a0q\u00a0\n                      <jats:sc>am<\/jats:sc>\n                      , 4\u00a0mg\u00a0q\u00a0\n                      <jats:sc>pm<\/jats:sc>\n                      and 8\u00a0mg qhs by the end of week 2. Participants in both conditions received 5 medical management sessions. Information regarding alcohol use, craving, and\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      was gathered daily using a telephone interactive voice response system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants randomized to prazosin had a greater reduction in percent days drinking per week and percent days heavy drinking per week between baseline and week 6 than did placebo participants. No significant differences were detected within or between groups in change from weeks 1 to 6 in total\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      symptoms. Participants in the prazosin condition reported drowsiness on significantly more days than those in the placebo condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Consistent with the extant research evaluating medications for comorbid\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      , the current evaluation of prazosin also found decreased alcohol consumption but no medication effect on\n                      <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>\n                      symptomatology.\n                    <\/jats:p>\n                  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