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Alcoholic fatty liver disease can progress to steatohepatitis, alcoholic hepatitis, fibrosis, and cirrhosis. Patients with alcohol abuse show quantitative and qualitative changes in the composition of the intestinal microbiome. Furthermore, patients with<jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>have increased intestinal permeability and elevated systemic levels of gut\u2010derived microbial products. Maintaining eubiosis, stabilizing the mucosal gut barrier, or preventing cellular responses to microbial products protect from experimental<jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>. Therefore, intestinal dysbiosis and pathological bacterial translocation appear fundamental for the pathogenesis of<jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>. This review highlights causes for intestinal dysbiosis and pathological bacterial translocation, their relationship, and consequences for<jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>. We also discuss how the liver affects the intestinal microbiota.<\/jats:p>","DOI":"10.1111\/acer.12704","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T19:04:30Z","timestamp":1429038270000},"page":"763-775","source":"Crossref","is-referenced-by-count":273,"title":["Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk"],"prefix":"10.1111","volume":"39","author":[{"given":"Phillipp","family":"Hartmann","sequence":"first","affiliation":[{"name":"Department of Medicine University of California, San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline T.","family":"Seebauer","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego La Jolla California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schnabl","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California, San Diego 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