{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:57:25Z","timestamp":1760061445585},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Rural Development Administration, Rebublic of Korea","award":["PJ00875501"],"award-info":[{"award-number":["PJ00875501"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study was performed to evaluate the effect and safety of a high\u2010gamma\u2010aminobutyric acid\u2010containing extract (GABA extract) of black sticky rice with giant embryo (BSRGE) on alcohol\u2010related indices after acute alcohol intake in social drinkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were randomized to the GABA extract (G) group, GABA extract and alcohol drinking (GA) group, or placebo intake and alcohol drinking (PA) group in a double\u2010blind design. All subjects were administered GABA extract (200\u00a0mg GABA) or placebo at 9 <jats:sc>am<\/jats:sc> on study days 2 and 3, respectively. Subjects in the GA and PA groups were administered an equivalent dose of alcohol that was diluted in a drinking beverage for a total amount of 240\u00a0ml at 11 <jats:sc>am<\/jats:sc> on day 3. Blood alcohol concentration (BAC) and the Biphasic Alcohol Effects Scale were measured just before alcohol drinking, and 6 times after alcohol drinking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The peak and area under the curve (AUC) of the total stimulation scale score after alcohol intake in females were significantly higher in the GA than in the PA group, whereas no significant difference was found between the 2 groups in males. The peak and AUC of the total score on the sedation scale after alcohol intake in males were significantly lower in the GA than in the PA group, whereas both were significantly higher in the GA than in the PA group of females. The AUC for BAC in males was significantly lower in the GA than in the PA group, whereas no significant difference was found in females. No adverse events were reported in any of the groups including the G group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coadministration of a GABA extract to social drinkers while drinking alcohol is supposed to affect alcohol\u2010related indices in terms of pharmacodynamics and pharmacokinetics and did not induce any adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12746","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T12:35:11Z","timestamp":1432298111000},"page":"1212-1218","source":"Crossref","is-referenced-by-count":6,"title":["Effect of GABA Extract of Black Sticky Rice with Giant Embryo on Alcohol\u2010Related Indices After Acute Alcohol Intake in Social Drinkers"],"prefix":"10.1111","volume":"39","author":[{"given":"Woo\u2010Young","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Psychiatry Pusan National University Yangsan Hospital Yangsan 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