{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:54:28Z","timestamp":1775858068431,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Network on Addictive Disorders","award":["RD12\/0028\/0018"],"award-info":[{"award-number":["RD12\/0028\/0018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The goal of this study was to estimate excess death due to external causes among 18\u2010 to 64\u2010year\u2010olds with alcohol use disorder (AUD) who were treated at public outpatient treatment centers, and the time elapsed from treatment initiation to death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective longitudinal study among 7,012 outpatients aged 18 to 64\u00a0years who began treatment for AUD between 1997 and 2007. Deaths due to external causes (intentional and unintentional injuries) were monitored until the end of 2008. Person\u2010years (PY) of follow\u2010up and crude mortality rates (CMRs) were calculated for all study variables, for each sex, and for 2 age groups (18 to 34 and 35 to 64\u00a0years). Standardized mortality ratios (SMRs) were estimated by age group and sex. Survival was analyzed using the Kaplan\u2013Meier method and Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We recorded 114 deaths due to external causes. The CMR was 2.7 per 1,000 PY (95% confidence interval [CI]: 2.2 to 3.2), with significant gender differences only among younger individuals (CMR for males\u00a0=\u00a03.9 per 1,000 PY [95% CI: 2.2 to 5.5] and CMR for females\u00a0=\u00a02.8 per 1,000 PY [95% CI: 0.1 to 5.6]). Unintentional injury was the most common cause of death (<jats:italic>n<\/jats:italic>\u00a0=\u00a065), of which acute poisoning (<jats:italic>n<\/jats:italic>\u00a0=\u00a025; 38.5%) and traffic accidents (<jats:italic>n<\/jats:italic>\u00a0=\u00a015; 23.1%) were the most prevalent. Suicide accounted for 91.8% (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) of deaths from intentional injuries. The excess of mortality between the AUD group and the general population (SMR) was 9.5 higher than in the general population (95% CI: 7.9 to 11.4), with significant differences between genders (SMR\u00a0=\u00a06.1 [95% CI: 4.9 to 7.5] in males and SMR\u00a0=\u00a020.4 [95% CI: 13.9 to 29.9] in females). Approximately 35% of deaths among individuals aged &lt;35\u00a0years and 60% among women occurred within a year of initiating treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the importance of excess of mortality among people with AUD and patients' vulnerability during the initial years of treatment. Preventing premature deaths due to external causes among women and younger patients with AUD is a priority.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12755","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T19:02:45Z","timestamp":1432926165000},"page":"1158-1165","source":"Crossref","is-referenced-by-count":11,"title":["Injury\u2010Related Mortality Over 12\u00a0Years in a Cohort of Patients with Alcohol Use Disorders: Higher Mortality Among Young People and Women"],"prefix":"10.1111","volume":"39","author":[{"given":"Anna M.","family":"Guitart","sequence":"first","affiliation":[{"name":"Ag\u00e8ncia de Salut P\u00fablica de Barcelona (ASPB) Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Espelt","sequence":"additional","affiliation":[{"name":"Ag\u00e8ncia de Salut P\u00fablica de Barcelona (ASPB) Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) Barcelona Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Madrid Spain"},{"name":"Departament de Psicobiologia i Metodologia de les Ci\u00e8ncies de la Salut Universitat Aut\u00f3noma de Barcelona Bellaterra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Castellano","sequence":"additional","affiliation":[{"name":"Ag\u00e8ncia de Salut P\u00fablica de Barcelona (ASPB) Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M.","family":"Suelves","sequence":"additional","affiliation":[{"name":"Ag\u00e8ncia de Salut P\u00fablica de Catalunya (ASPCAT) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan R.","family":"Villalb\u00ed","sequence":"additional","affiliation":[{"name":"Ag\u00e8ncia de Salut P\u00fablica de Barcelona (ASPB) Barcelona Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica Sant Pau (IIB Sant Pau) Barcelona Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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