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While early evidence suggests altered functional brain connectivity in the lateralization of motor networks in school\u2010age children with prenatal alcohol exposure (<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>), the specific effects of alcohol exposure on the establishment of intrinsic connectivity in early infancy have not been explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty subjects received functional imaging at 2 to 4\u00a0weeks of age for 6 to 8\u00a0minutes during quiet natural sleep. Thirteen alcohol\u2010exposed (<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>) and 14 age\u2010matched control (<jats:styled-content style=\"fixed-case\">CTRL<\/jats:styled-content>) participants with usable data were included in a multivariate model of connectivity between sensorimotor intrinsic functional connectivity networks. Seed\u2010based analyses of group differences in interhemispheric connectivity of intrinsic motor networks were also conducted. The Dubowitz neurological assessment was performed at the imaging visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol exposure was associated with significant increases in connectivity between somatosensory, motor networks, brainstem\/thalamic, and striatal intrinsic networks. Reductions in interhemispheric connectivity of motor and somatosensory networks did not reach significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although results are preliminary, findings suggest <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> may disrupt the temporal coherence in blood oxygenation utilization in intrinsic networks underlying motor performance in newborn infants. Studies that employ longitudinal designs to investigate the effects of in utero alcohol exposure on the evolving resting\u2010state networks will be key in establishing the distribution and timing of connectivity disturbances already described in older children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12930","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T23:52:29Z","timestamp":1451951549000},"page":"113-121","source":"Crossref","is-referenced-by-count":33,"title":["Interhemispheric Functional Brain Connectivity in Neonates with Prenatal Alcohol Exposure: Preliminary Findings"],"prefix":"10.1111","volume":"40","author":[{"given":"Kirsten A.","family":"Donald","sequence":"first","affiliation":[{"name":"Division of Developmental Paediatrics (KAD) Department of Paediatrics and Child Health Red Cross War Memorial Children's Hospital and University of Cape Town Cape Town South 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