{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:24:12Z","timestamp":1791300252602,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"NIAAA","doi-asserted-by":"crossref","award":["1R03AA021545-01"],"award-info":[{"award-number":["1R03AA021545-01"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In utero alcohol, or ethanol (EtOH), exposure produces developmental abnormalities in the brain of the fetus, which can result in lifelong behavioral abnormalities. Fetal alcohol spectrum disorders (<jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content>) is a term used to describe a range of adverse developmental conditions caused by EtOH exposure during gestation. Children diagnosed with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> potentially exhibit a host of phenotypes including growth retardation, facial dysmorphology, central nervous system anomalies, abnormal behavior, and cognitive deficits. Previous research suggests that abnormal gene expression and circuitry in the neocortex may underlie reported disabilities of learning, memory, and behavior resulting from early exposure to alcohol (<jats:italic>J Neurosci<\/jats:italic>, 33, 2013, 18893).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we utilize a mouse model of <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> to examine effects of prenatal EtOH exposure (PrEE), on brain anatomy in newborn (postnatal day [P]0), weanling (P20), and early adult (P50) mice. We correlate abnormal cortical and subcortical anatomy with atypical behavior in adult P50 Pr<jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content> mice. In this model, experimental dams self\u2010administered a 25% EtOH solution throughout gestation (gestational days 0 to 19, day of birth), generating the exposure to the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results from these experiments reveal long\u2010term alterations to cortical anatomy, including atypical developmental cortical thinning, and abnormal subcortical development as a result of in utero EtOH exposure. Furthermore, offspring exposed to EtOH during the prenatal period performed poorly on behavioral tasks measuring sensorimotor integration and anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insight from this study will help provide new information on developmental trajectories of Pr<jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content> and the biological etiologies of abnormal behavior in people diagnosed with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.12936","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T23:52:29Z","timestamp":1451951549000},"page":"122-133","source":"Crossref","is-referenced-by-count":54,"title":["The Impact of Prenatal Ethanol Exposure on Neuroanatomical and Behavioral Development in Mice"],"prefix":"10.1111","volume":"40","author":[{"given":"Charles 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