{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T10:34:50Z","timestamp":1726482890209},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp; Exp Res"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Background<\/jats:title>Osteoprotegerin (OPG<\/jats:styled-content>) is a parameter of increasing interest in the search for pathophysiological mechanisms of reduced bone mineral density (BMD<\/jats:styled-content>). It has been shown to be increased in alcohol\u2010dependent subjects. In our study, we wanted to examine whether changes in OPG<\/jats:styled-content> and receptor activator of the nuclear factor\u2010\u03ba<\/jats:italic>B<\/jats:styled-content> ligand (RANKL<\/jats:styled-content>) levels during an 8\u2010week abstinence period in alcohol\u2010dependent patients treated in an alcohol rehabilitation clinic would occur and whether alcohol\u2010related variables, smoking, status, or physical activity prior to the study served as an influence on BMD<\/jats:styled-content> and on OPG<\/jats:styled-content>\/RANKL<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010three patients, who were abstinent not longer than a week, were included in the study. OPG<\/jats:styled-content> and RANKL<\/jats:styled-content> as well as other markers of bone metabolism were measured at baseline, and after 8\u00a0weeks of treatment, BMD<\/jats:styled-content> was measured once.<\/jats:p><\/jats:sec>Results<\/jats:title>OPG levels decreased significantly, while osteocalcin, a marker of bone formation, increased significantly. RANKL<\/jats:styled-content> as well as RANKL<\/jats:styled-content>\/OPG<\/jats:styled-content> ratio, Serum CrossLaps, and all examined hormones showed no significant changes over time. Inflammatory parameters showed a significant reduction after 8\u00a0weeks. We detected no influence of potentially confounding variables of alcohol dependency on the course of OPG<\/jats:styled-content> or other laboratory values.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our results could point to the well\u2010known risk for reduced BMD<\/jats:styled-content> in these patients being reversible with abstinence through an excess of bone formation. We also confirmed earlier findings that inflammatory processes play a role in the pathogenesis of alcohol\u2010induced disturbances in bone metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13063","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T17:51:06Z","timestamp":1460310666000},"page":"1235-1240","source":"Crossref","is-referenced-by-count":4,"title":["Osteoprotegerin Levels Decrease in Abstinent Alcohol\u2010Dependent Patients"],"prefix":"10.1111","volume":"40","author":[{"given":"Peter","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Psychiatry & Psychotherapy Medical University of Innsbruck Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"von Gleissenthall","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Psychotherapy Medical University of Innsbruck Innsbruck 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