{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:38:43Z","timestamp":1772008723782,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T00:00:00Z","timestamp":1462406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alcoholic hepatitis (<jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content>) is a major cause of liver\u2010related hospitalization. The profile, treatment patterns, and outcomes of subjects admitted for <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> in routine clinical practice are unknown. Also, it is not known whether these are changing over time. This study is thus aimed to identify temporal trends in hospitalization rates, clinical characteristics, treatment patterns, and outcomes of subjects admitted for <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> in a routine clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of adults admitted for <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> from 2000 to 2011 was performed using an anonymized <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content> database of patient\u2010level data from 169 U.S. medical centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(i) <jats:italic>Epidemiology<\/jats:italic>: The proportion of baby boomers admitted for <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> increased from 2000 to 2011 (26 to 31%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). (ii) <jats:italic>Clinical<\/jats:italic>: The median Model for End\u2010Stage Liver Disease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>) score increased over time from 12 to 14 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0014) driven mainly by increased international normalized ratio (1.2 to 1.4, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). The median Charlson Comorbidity Index increased from 0 to 1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) with increased diabetes, chronic obstructive pulmonary disease, and heart disease. (iii) <jats:italic>Complications<\/jats:italic>: The following increased from 2001 to 2011: Gastrointestinal bleed\u20147 to 10% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03); hepatic encephalopathy\u20147 to 13% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001); hepatorenal syndrome\u20141.8 to 2.8% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0003); sepsis\u20140 to 6% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001); and pancreatitis\u201411 to 16% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0061). (iv) <jats:italic>Treatment patterns and mortality<\/jats:italic>: Eight to 9% of subjects received steroids while pentoxifylline use increased to 2.2%. In those with <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>\u00a0\u2265\u00a022, mortality remained between 19 and 20% and only steroids modestly improved survival in this subset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> continues to have a high mortality. The severity and comorbidities and complications associated with <jats:styled-content style=\"fixed-case\">AH<\/jats:styled-content> have worsened. Drug therapy remains suboptimal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13069","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T12:26:46Z","timestamp":1462451206000},"page":"1295-1303","source":"Crossref","is-referenced-by-count":33,"title":["The Worsening Profile of Alcoholic Hepatitis in the United States"],"prefix":"10.1111","volume":"40","author":[{"given":"Tuyet A.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Virginia Commonwealth University School of Medicine Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"DeShazo","sequence":"additional","affiliation":[{"name":"Department of Health Administration Virginia Commonwealth University School of Medicine Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leroy R.","family":"Thacker","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Virginia Commonwealth University School of Medicine Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Virginia Commonwealth University School of Medicine Richmond Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun J.","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Virginia Commonwealth University School of Medicine Richmond 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