{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:42:12Z","timestamp":1791855732453,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA014834"],"award-info":[{"award-number":["U01 AA014834"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U24 AA014811"],"award-info":[{"award-number":["U24 AA014811"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U24 AA014815"],"award-info":[{"award-number":["U24 AA014815"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["F31 AA022261"],"award-info":[{"award-number":["F31 AA022261"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurobehavioral consequences of heavy prenatal alcohol exposure are well documented; however, the role of age or sex in these effects has not been studied. The current study examined the effects of prenatal alcohol exposure, sex, and age on neurobehavioral functioning in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Subjects were 407 youth with prenatal alcohol exposure (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      192) and controls (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      215). Two age groups (child [5 to 7\u00a0years] or adolescent [10 to 16\u00a0years]) and both sexes were included. All subjects completed standardized neuropsychological testing, and caregivers completed parent\u2010report measures of psychopathology and adaptive behavior. Neuropsychological functioning, psychopathology, and adaptive behavior were analyzed with separate 2 (exposure history)\u00a0\u00d7\u00a02 (sex)\u00a0\u00d7\u00a02 (age) multivariate analyses of variance (MANOVAs). Significant effects were followed by univariate analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No 3\u2010way or 2\u2010way interactions were significant. The main effect of group was significant in all 3\n                      <jats:styled-content style=\"fixed-case\">MANOVA<\/jats:styled-content>\n                      s, with the control group performing better than the alcohol\u2010exposed group on all measures. The main effect of age was significant for neuropsychological performance and adaptive functioning across exposure groups with younger children performing better than older children on 3 measures (language, communication, socialization). Older children performed better than younger children on a different language measure. The main effect of sex was significant for neuropsychological performance and psychopathology; across exposure groups, males had stronger language and visual spatial scores and fewer somatic complaints than females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prenatal alcohol exposure resulted in impaired neuropsychological and behavioral functioning. Although adolescents with prenatal alcohol exposure may perform more poorly than younger exposed children, the same was true for nonexposed children. Thus, these cross\u2010sectional data indicate that the developmental trajectory for neuropsychological and behavioral performance is not altered by prenatal alcohol exposure, but rather, deficits are consistent across the 2 age groups tested. Similarly, observed sex differences on specific measures were consistent across the groups and do not support sexually dimorphic effects in these domains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.13153","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T07:43:04Z","timestamp":1468914184000},"page":"1971-1981","source":"Crossref","is-referenced-by-count":48,"title":["Neurobehavioral Deficits Consistent Across Age and Sex in Youth with Prenatal Alcohol Exposure"],"prefix":"10.1111","volume":"40","author":[{"given":"Amy L.","family":"Panczakiewicz","sequence":"first","affiliation":[{"name":"Department of Psychology Center for Behavioral Teratology San Diego State University San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Psychology Center for Behavioral Teratology San Diego State University San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire D.","family":"Coles","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia"},{"name":"Department of Pediatrics Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Kable","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Sowell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Developmental Cognitive Neuroimaging Laboratory Keck School of Medicine University of Southern California Los Angeles California"},{"name":"Division of Research on Children, Youth, and Families Department of Pediatrics Children's Hospital Los Angeles Los Angeles 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