{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:51:01Z","timestamp":1783745461711,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp; Exp Res"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Background<\/jats:title>Cue\u2010evoked drug\u2010seeking behavior likely depends on interactions between frontal activity and ventral striatal (VST<\/jats:styled-content>) dopamine (DA) transmission. Using [11<\/jats:sup>C]raclopride (RAC<\/jats:styled-content>) positron emission tomography (PET<\/jats:styled-content>), we previously demonstrated that beer flavor (absent intoxication) elicited VST DA<\/jats:styled-content> release in beer drinkers, inferred by RAC<\/jats:styled-content> displacement. Here, a subset of subjects from this previous RAC<\/jats:styled-content>\u2010PET<\/jats:styled-content> study underwent a similar paradigm during functional magnetic resonance imaging (fMRI<\/jats:styled-content>) to test how orbitofrontal cortex (OFC<\/jats:styled-content>) and VST<\/jats:styled-content> blood oxygenation level\u2010dependent (BOLD<\/jats:styled-content>) responses to beer flavor are related to VST DA<\/jats:styled-content> release and motivation to drink.<\/jats:p><\/jats:sec>Methods<\/jats:title>Male beer drinkers (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>28, age\u00a0<\/jats:italic>=\u00a0<\/jats:italic>24\u00a0\u00b1\u00a02, drinks\/wk\u00a0<\/jats:italic>=\u00a0<\/jats:italic>16\u00a0\u00b1\u00a010) from our previous PET<\/jats:styled-content> study participated in a similar fMRI<\/jats:styled-content> paradigm wherein subjects tasted their most frequently consumed brand of beer and Gatorade\u00ae<\/jats:sup> (appetitive control). We tested for correlations between BOLD<\/jats:styled-content> activation in fMRI<\/jats:styled-content> and VST DA<\/jats:styled-content> responses in PET<\/jats:styled-content>, and drinking\u2010related variables.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared to Gatorade, beer flavor increased wanting and desire to drink, and induced BOLD<\/jats:styled-content> responses in bilateral OFC<\/jats:styled-content> and right VST<\/jats:styled-content>. Wanting and desire to drink correlated with both right VST<\/jats:styled-content> and medial OFC BOLD<\/jats:styled-content> activation to beer flavor. Like the BOLD<\/jats:styled-content> findings, beer flavor (relative to Gatorade) again induced right VST DA<\/jats:styled-content> release in this fMRI<\/jats:styled-content> subject subset, but there was no correlation between DA<\/jats:styled-content> release and the magnitude of BOLD<\/jats:styled-content> responses in frontal regions of interest.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Both imaging modalities showed a right\u2010lateralized VST<\/jats:styled-content> response (BOLD<\/jats:styled-content> and DA<\/jats:styled-content> release) to a drug\u2010paired conditioned stimulus, whereas fMRI BOLD<\/jats:styled-content> responses in the VST<\/jats:styled-content> and medial OFC<\/jats:styled-content> also reflected wanting and desire to drink. The data suggest the possibility that responses to drug\u2010paired cues may be rightward biased in the VST<\/jats:styled-content> (at least in right\u2010handed males) and that VST<\/jats:styled-content> and OFC<\/jats:styled-content> responses in this gustatory paradigm reflect stimulus wanting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13158","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T22:02:38Z","timestamp":1469570558000},"page":"1865-1873","source":"Crossref","is-referenced-by-count":30,"title":["Corticostriatal and Dopaminergic Response to Beer Flavor with Both fMRI and [11<\/sup>C]raclopride Positron Emission Tomography"],"prefix":"10.1111","volume":"40","author":[{"given":"Brandon G.","family":"Oberlin","sequence":"first","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine (IUSM) Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dzemidzic","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine (IUSM) Indianapolis Indiana"},{"name":"Department of Radiology and Imaging Sciences Center for Neuroimaging IUSM Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Harezlak","sequence":"additional","affiliation":[{"name":"Department of Biostatistics IUSM Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Kudela","sequence":"additional","affiliation":[{"name":"Department of Biostatistics IUSM Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella M.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine (IUSM) Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Soeurt","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine (IUSM) Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karmen K.","family":"Yoder","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Center for Neuroimaging IUSM Indianapolis Indiana"},{"name":"Stark Neurosciences Research Institute IUSM Indianapolis Indiana"},{"name":"Department of Psychology Indiana University Purdue University Indianapolis Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Kareken","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine (IUSM) Indianapolis Indiana"},{"name":"Department of Radiology and Imaging Sciences Center for Neuroimaging IUSM Indianapolis Indiana"},{"name":"Stark Neurosciences Research Institute IUSM Indianapolis Indiana"},{"name":"Department of Psychology Indiana University Purdue University Indianapolis Indianapolis Indiana"},{"name":"Department of Psychiatry IUSM Indianapolis 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