{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:42:06Z","timestamp":1772736126844,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AA013892\u201010"],"award-info":[{"award-number":["R01\u2010AA013892\u201010"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2013AA20504\u201003"],"award-info":[{"award-number":["R01\u2013AA20504\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1\u2013DE19856"],"award-info":[{"award-number":["UL1\u2013DE19856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PL1\u2010DA024859"],"award-info":[{"award-number":["PL1\u2010DA024859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08\u2010AA023545\u201002"],"award-info":[{"award-number":["K08\u2010AA023545\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Stress triggers impulsive and addictive behaviors, and alcoholism has been frequently associated with increased stress sensitivity and impulse control problems. However, neural correlates underlying the link between alcoholism and impulsivity in the context of stress in patients with alcohol use disorders (<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>) have not been well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study investigated neural correlates and connectivity patterns associated with impulse control difficulties in abstinent<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>patients. Using functional magnetic resonance imaging, brain responses of 37<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>inpatients, and 37 demographically matched healthy controls were examined during brief individualized imagery trials of stress, alcohol cue, and neutral\u2010relaxing conditions. Stress\u2010related impulsivity was measured using a subscale score of impulse control problems from Difficulties in Emotion Regulation Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Impulse control difficulties in<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>patients were significantly associated with hypo\u2010active response to stress in the ventromedial prefrontal cortex (Vm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>), right caudate, and left lateral PFC (<jats:styled-content style=\"fixed-case\">LPFC<\/jats:styled-content>) compared to the neutral condition (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, whole\u2010brain corrected). These regions were used as seed regions to further examine the connectivity patterns with other brain regions. With the VmPFC seed,<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>patients showed reduced connectivity with the anterior cingulate cortex compared to controls, which are core regions of emotion regulation, suggesting<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>patients' decreased ability to modulate emotional response under distressed state. With the right caudate seed, patients showed increased connectivity with the right motor cortex, suggesting increased tendency toward habitually driven behaviors. With the left<jats:styled-content style=\"fixed-case\">LPFC<\/jats:styled-content>seed, decreased connectivity with the dorsomedial<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>(Dm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>), but increased connectivity with sensory and motor cortices were found in<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>patients compared to controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, whole\u2010brain corrected). Reduced connectivity between the left<jats:styled-content style=\"fixed-case\">LPFC<\/jats:styled-content>and Dm<jats:styled-content style=\"fixed-case\">PFC<\/jats:styled-content>was further associated with increased stress\u2010induced anxiety in<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, with adjusted Bonferroni correction).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypo\u2010active response to stress and altered connectivity in key emotion regulatory regions may account for greater stress\u2010related impulse control problems in alcoholism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13166","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T20:19:27Z","timestamp":1470687567000},"page":"1884-1894","source":"Crossref","is-referenced-by-count":34,"title":["Neural Correlates and Connectivity Underlying Stress\u2010Related Impulse Control Difficulties in Alcoholism"],"prefix":"10.1111","volume":"40","author":[{"given":"Dongju","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl M.","family":"Lacadie","sequence":"additional","affiliation":[{"name":"Department of Radiology Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajita","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut"},{"name":"Department of Neurobiology and Child Study Center Yale School of Medicine New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2648"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2509"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1554-07.2007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(02)00015-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.7.4.356"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.09.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903630408"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1080\/01621459.1972.10481273","article-title":"Estimates of parameters of a censored regression sample","volume":"67","author":"Chen EH","year":"1972","journal-title":"J Am Stat Assoc"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2152-14.2014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbmr.1996.0014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21333"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12266"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5479.591"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177705900"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.027"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2009_5"},{"key":"e_1_2_7_18_1","first-page":"162","article-title":"An epidemiologic analysis of co\u2010occurring alcohol and tobacco use and disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"29","author":"Falk DE","year":"2006","journal-title":"Alcohol Res Health"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4135"},{"key":"e_1_2_7_20_1","unstructured":"2002 Biometrics Research New York State Psychiatric Institute New York NY MB First RL Spitzer M Gibbon B Janet Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders Research Version"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.12.026"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1111\/j.1530-0277.2010.01221.x","article-title":"Interactive effects of cumulative stress and impulsivity on alcohol consumption","volume":"34","author":"Fox HC","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2007.10.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350312"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOBA.0000007455.08539.94"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199803000-00032"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3904-10.2011"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.06.012"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.5.776"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1216356"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01224.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1835"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119971109"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.167"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90461-4"},{"issue":"2","key":"e_1_2_7_36_1","first-page":"S246","article-title":"XMedCon\u2010 an open\u2010source medical image conversion toolkit","volume":"30","author":"Nolfe E","year":"2003","journal-title":"Eur J Nucl Med"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.11020289"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01214.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3377-1"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.04.002"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-11-04049.1988"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21165"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.762"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avb.2008.06.003"},{"key":"e_1_2_7_46_1","first-page":"211","volume-title":"Neuroimaging in the Addictions","author":"Seo D","year":"2011"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256254"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1441.030"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2008.00134.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.78"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.49"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595230601036960"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01875.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3215-05.2006"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nst065"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460030404"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.13166","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.13166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.13166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T19:40:24Z","timestamp":1718739624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.13166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/acer.13166"],"URL":"https:\/\/doi.org\/10.1111\/acer.13166","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]}}}