{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:06:18Z","timestamp":1780603578164,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000838","name":"University of Sussex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000838","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Youths with family history (FH) of alcoholism are at greater risk of developing alcohol use disorder (<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>); heightened impulsive behavior may underlie such increased vulnerability. Here, we studied waiting impulsivity (previously suggested to predispose to alcohol drinking) in young moderate\u2010to\u2010heavy social drinkers (18 to 33\u00a0years old) characterized as family history positive (<jats:styled-content style=\"fixed-case\">FHP<\/jats:styled-content>) and negative (<jats:styled-content style=\"fixed-case\">FHN<\/jats:styled-content>) following an alcoholic or nonalcoholic (placebo) drink.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two groups of young male and female social drinkers (<jats:italic>n<\/jats:italic>\u00a0=\u00a064) were administered an acute dose of alcohol (0.8\u00a0g\/kg) or placebo. One group (<jats:styled-content style=\"fixed-case\">FHP<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a024) had first\u2010degree relatives with problems of alcohol misuse; the other group (FHN) did not. Participants completed 4 variants of the Sx\u20105CSRTT, a task measuring waiting impulsivity. In addition, other types of impulsive behavior were tested (by means of the stop\u2010signal task [SST]; information sampling task [IST]; Delay Discounting Questionnaire; 2\u2010choice impulsivity paradigm; and time estimation task).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Young <jats:styled-content style=\"fixed-case\">FHP<\/jats:styled-content> adults showed more premature responding than <jats:styled-content style=\"fixed-case\">FHN<\/jats:styled-content> when evaluated under increased attentional load (high waiting impulsivity), while, in contrast, they presented a more conservative strategy on the <jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content> (less impulsive behavior), compared to <jats:styled-content style=\"fixed-case\">FHN<\/jats:styled-content>. Acute alcohol impaired inhibitory control on the <jats:styled-content style=\"fixed-case\">SST<\/jats:styled-content> in all participants, and induced a marginal increase of premature responses, but did not affect other measures of impulsivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Assessing for exaggerated waiting impulsivity may provide a potential endophenotype associated with risk for the development of alcohol addiction (i.e., offspring of alcoholics).<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13184","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T21:02:56Z","timestamp":1472245376000},"page":"2208-2217","source":"Crossref","is-referenced-by-count":34,"title":["Heightened Impulsivity: Associated with Family History of Alcohol Misuse, and a Consequence of Alcohol 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