{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:37:19Z","timestamp":1777588639436,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000161","name":"Networks of Centres of Excellence of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Saccades are rapid eye movements that bring an image of interest onto the retina. Previous research has found that in healthy individuals performing eye movement tasks, the location of a previous visual target can influence performance of the saccade on the next trial. This rapid behavioral adaptation represents a form of immediate neural plasticity within the saccadic circuitry. Our studies have shown that children with fetal alcohol spectrum disorder (<jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content>) are impaired on multiple saccade measures. We therefore investigated these previous trial effects in typically developing children and children with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> to measure sensory neural plasticity and how these effects vary with age and pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Both typically developing control children (<jats:italic>n<\/jats:italic>\u00a0=\u00a0102; mean age\u00a0=\u00a010.54\u00a0\u00b1\u00a03.25; 48 males) and children with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a066; mean age\u00a0=\u00a011.85\u00a0\u00b1\u00a03.42; 35 males) were recruited from 5 sites across Canada. Each child performed a visually guided saccade task. Reaction time and saccade amplitude were analyzed and then assessed based on the previous trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a robust previous trial effect for both reaction time and amplitude, with both the control and <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> groups displaying faster reaction times and smaller saccades during alternation trials (visual target presented on the opposite side to the previous trial). Children with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> exhibited smaller overall mean amplitude and smaller amplitude selectively on alternation trials compared with controls. The effect of the previous trial on reaction time and amplitude did not differ across childhood and adolescent development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> did not display any significant reaction time differences, despite exhibiting numerous deficits in motor and higher level cognitive control over saccades in other studies. These results suggest that this form of immediate neural plasticity in response to sensory information before saccade initiation remains intact in children with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content>. In contrast, the previous trial effect on amplitude suggests that the motor component of saccades may be affected, signifying differential vulnerability to prenatal alcohol exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13224","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T12:22:39Z","timestamp":1474546959000},"page":"2351-2358","source":"Crossref","is-referenced-by-count":2,"title":["Immediate Neural Plasticity Involving Reaction Time in a Saccadic Eye Movement Task is Intact in Children With Fetal Alcohol Spectrum Disorder"],"prefix":"10.1111","volume":"40","author":[{"given":"Angelina","family":"Paolozza","sequence":"first","affiliation":[{"name":"Centre for Neuroscience Studies Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas P.","family":"Munoz","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience Studies Queen's University Kingston Ontario 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