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Alcohol consumption is associated with some health problems such as neurological, cognitive, behavioral deficits, cancer, heart, and liver disease. Mechanisms of alcohol\u2010induced toxicity are presently not yet clear. One of the mechanisms underlying alcohol toxicity has to do with its interaction with amino acid homocysteine (Hcy), which has been linked with brain neurotoxicity. Elevated Hcy impairs with various physiological mechanisms in the body, especially metabolic pathways. Hcy metabolism is predominantly controlled by epigenetic regulation such as\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    methylation, histone modifications, and acetylation. An alteration in these processes leads to epigenetic modification. Therefore, in this review, we summarize the role of Hcy metabolism abnormalities in alcohol\u2010induced toxicity with epigenetic adaptation and their influences on cerebrovascular pathology.\n                  <\/jats:p>","DOI":"10.1111\/acer.13234","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T08:04:40Z","timestamp":1478073880000},"page":"2474-2481","source":"Crossref","is-referenced-by-count":52,"title":["Homocysteine, Alcoholism, and Its Potential Epigenetic Mechanism"],"prefix":"10.1111","volume":"40","author":[{"given":"Pradip K.","family":"Kamat","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine University of Louisville Louisville Kentucky"},{"name":"Department of Anesthesiology Center for Translational Research in Neurodegenerative Disease College of Medicine, University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa 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