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Patterns of performance were examined in 2 subject groups: children with heavy prenatal alcohol exposure (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>67) and controls (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>61). A repeated\u2010measures <jats:styled-content style=\"fixed-case\">MANCOVA<\/jats:styled-content> examining group differences on academic domain (reading, spelling, math) scores was conducted. Post hoc comparisons examined within\u2010group profiles. Numbers and percentage of children with low achievement were calculated using several criteria. In a subsample (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>42), neural correlates were analyzed using FreeSurfer v5.3 to examine relations between cortical structure (thickness and surface area) and performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The alcohol\u2010exposed group performed worse than controls on all domains and had a unique academic profile, supported by a significant group\u00a0\u00d7\u00a0academic domain interaction (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). For the alcohol\u2010exposed group, math reasoning was significantly lower than numerical operations, which was significantly lower than spelling and word reading. Over half of the alcohol\u2010exposed group (58.2%) demonstrated low achievement on 1 or more academic domains. The number and percentage of children meeting criteria for low achievement varied based on the domain and definition used. The imaging analysis identified several surface area clusters that were differentially related to math (L superior parietal and R lateral\/middle occipital) and spelling (bilateral inferior and medial temporal) performance by group, with no relations for the other academic domains. Generally, scores improved as surface area decreased in controls, whereas no relation or a positive relation was observed in the alcohol\u2010exposed group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alcohol\u2010exposed children demonstrated deficits in academic performance across domains and definitions, with a relative weakness in math functioning. Atypical brain development may contribute to these impairments in academic achievement. Understanding academic difficulties can assist in advocating effectively for alcohol\u2010exposed children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13366","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T09:04:24Z","timestamp":1490432664000},"page":"1024-1034","source":"Crossref","is-referenced-by-count":34,"title":["Academic Difficulties in Children with Prenatal Alcohol Exposure: Presence, Profile, and Neural Correlates"],"prefix":"10.1111","volume":"41","author":[{"given":"Leila","family":"Glass","sequence":"first","affiliation":[{"name":"Department of Psychology  Center for Behavioral Teratology San Diego State University San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychology  Center for Behavioral Teratology San Diego State University San Diego 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