{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:34:12Z","timestamp":1785893652315,"version":"3.56.0"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R37 AA011290"],"award-info":[{"award-number":["R37 AA011290"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["F32 AA023422"],"award-info":[{"award-number":["F32 AA023422"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Alcoholic cardiomyopathy (<jats:styled-content style=\"fixed-case\">ACM<\/jats:styled-content>) can develop after consumption of relatively large amounts of alcohol over time or from acute binge drinking. Of the many factors implicated in the etiology of <jats:styled-content style=\"fixed-case\">ACM<\/jats:styled-content>, chronic perturbation in protein balance has been strongly implicated. This review focused on recent contributions (since 2010) in the area of protein metabolism and cardiac function related to <jats:styled-content style=\"fixed-case\">ACM<\/jats:styled-content>. Data reviewed include that from in\u00a0vitro and preclinical in\u00a0vivo animal studies where alcohol or an oxidative metabolite was studied and outcome measures in either cardiomyocytes or whole heart pertaining to protein synthesis or degradation were reported. Additionally, studies on the contractile properties of cardiomyocytes were also included to link signal transduction with function. Methodological differences including the potential impact of sex, dosing, and duration\/timing of alcohol administration are addressed. Acute and chronic alcohol consumption decreases cardiac protein synthesis and\/or activation of proteins within the regulatory mammalian\/mechanistic target of rapamycin complex pathway. Albeit limited, evidence suggests that myocardial protein degradation via the ubiquitin pathway is not altered, while autophagy may be enhanced in <jats:styled-content style=\"fixed-case\">ACM<\/jats:styled-content>. Alcohol impairs ex\u00a0vivo cardiomyocyte contractility in relation to its metabolism and expression of proteins within the growth factor pathway. Dysregulation of protein metabolism, including the rate of protein synthesis and autophagy, may contribute to contractile deficits and is a hallmark feature of <jats:styled-content style=\"fixed-case\">ACM<\/jats:styled-content> meriting additional sex\u2010inclusive, methodologically consistent studies.<\/jats:p>","DOI":"10.1111\/acer.13405","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T06:13:19Z","timestamp":1492668799000},"page":"1392-1401","source":"Crossref","is-referenced-by-count":29,"title":["Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility"],"prefix":"10.1111","volume":"41","author":[{"given":"Jennifer L.","family":"Steiner","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Physiology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3260-7363","authenticated-orcid":false,"given":"Charles H.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Physiology Penn State College of Medicine Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12425"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-490X-1-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2010.42.3.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01194.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1617608"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.04.030"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2013.12.057"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00465.2013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells5020024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.08.002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01158.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01347.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/ags090"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.18997"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008757"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs127"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011268"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000075823.73536.DD"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12363"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb839"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319270010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2152"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.10.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12343"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00177.2003"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.5.E1029"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb04614.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.04.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(00)00081-9"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00414.2013"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.2.E268"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.03.017"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00319.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.03.017"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1599207"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1574"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(99)00096-9"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072873"},{"key":"e_1_2_7_41_1","first-page":"241","article-title":"Alcoholic cardiomyopathy: clinical and experimental pathological changes","volume":"21","author":"Preedy VR","year":"1996","journal-title":"Herz"},{"key":"e_1_2_7_42_1","first-page":"825","article-title":"Acetaldehyde depresses shortening and intracellular Ca2+ transients in adult rat ventricular myocytes","volume":"43","author":"Ren J","year":"1997","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010grand)"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2002.0947"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753944708095137"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302022"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00860.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(85)90266-6"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12459"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00440.2004"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2007.00544.x"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.5.E1045"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-008-9012-4"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.3.H1242"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000121653.80502.54"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi902135e"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.03.005"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.12.018"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.07.020"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.08.014"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2004.01.005"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.13405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.13405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:19:31Z","timestamp":1696483171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.13405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,29]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/acer.13405"],"URL":"https:\/\/doi.org\/10.1111\/acer.13405","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,29]]}}}