{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:22:07Z","timestamp":1793946127787,"version":"4.8.0"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Blood brain\u2010derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) levels are influenced by both addiction and mood disorders, as well as somatic conditions, gender, and genetic polymorphisms, leading to widely varying results. Depressive symptoms and episodes are frequently observed in patients with alcohol use disorder, and vary widely over time, making it a challenge to determine which aspects are specifically involved in variations of serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed 227 patients with alcohol dependence involved in a detoxification program, at baseline and after a follow\u2010up of 6\u00a0months, for the Alcohol Use Disorders Identification Test score, the length of alcohol dependence, and the number of past detoxification programs. The Beck Depression Inventory and information on current tobacco and alcohol use, suicidal ideation, body mass index, age, gender, and psychotropic treatments were also collected. Serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) and 2 genetic polymorphisms of the <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> gene (Val33Met and rs962369) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of the Met\u00a0allele, 2 markers of the history of alcohol dependence (gamma glutamyl transferase and the number of past treatments in detoxification programs), and the presence of a depressive episode (but not depressive score) were significantly associated with the 2 blood levels of <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> at baseline and after 6\u00a0months. After controlling for baseline <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels, the presence of the Met\u00a0allele and an ongoing depressive episode were the only variables associated with changes in <jats:styled-content style=\"fixed-case\">BNDF<\/jats:styled-content> levels after 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels are associated with characteristics related to alcohol consumption and mood disorders, and variants of the <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> gene in alcohol use disorder patients. The factors that most strongly influenced changes in serum <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> levels following treatment in an alcohol detoxification program were variants of the <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> gene and ongoing depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13414","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T14:43:21Z","timestamp":1494341001000},"page":"1280-1287","source":"Crossref","is-referenced-by-count":31,"title":["Determinants of Blood Brain\u2010Derived Neurotrophic Factor Blood Levels in Patients with Alcohol Use Disorder"],"prefix":"10.1111","volume":"41","author":[{"given":"Philippe","family":"Nubukpo","sequence":"first","affiliation":[{"name":"P\u00f4le d'Addictologie Centre Hospitalier Esquirol Limoges France"},{"name":"Unit\u00e9 de Recherche et de Neurostimulation Centre Hospitalier Esquirol Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Ramoz","sequence":"additional","affiliation":[{"name":"Inserm UMR894 Centre de Psychiatrie et Neurosciences Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-0329","authenticated-orcid":false,"given":"Murielle","family":"Girard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche et de Neurostimulation Centre Hospitalier Esquirol Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Malauzat","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche et de Neurostimulation Centre Hospitalier Esquirol Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Gorwood","sequence":"additional","affiliation":[{"name":"Inserm UMR894 Centre de Psychiatrie et Neurosciences Paris France"},{"name":"Clinique des Maladies Mentales et de l'Enc\u00e9phale (CMME) H\u00f4pital Sainte\u2010Anne Universit\u00e9 Paris Descartes Paris Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.12.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2011.580567"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(88)90050-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.07.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001723308"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009309"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336997"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.07.013"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03074.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191194001001004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)46018-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08148"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22575"},{"key":"e_1_2_10_17_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01548.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9790-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07040574"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-012-1145-7"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1929"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0584"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1995.56.168"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00742.2003"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(10)70354-6"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35075076"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300192"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-10-04110.1999"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agm172"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.11.004"},{"key":"e_1_2_10_33_1","first-page":"Unit 2.10","article-title":"Genotyping using the TaqMan assay","volume":"2","author":"Hui L","year":"2008","journal-title":"Curr Protoc Hum Genet"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050212-185610"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1870"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1824"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(02)00005-7"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00529-3"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.06.043"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.010967"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.80"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5124-03.2004"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301571"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3714-04.2004"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2850.2009.01469.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0837"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03160-8"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-011-0189-3"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.105"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10329-002-0015-7"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622970701263303"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2010.00578.x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2006.12.009"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2009.06.022"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00141-5"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.12.020"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)71476-2"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.81"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01321-0"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.06.027"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.69"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.05.005"},{"key":"e_1_2_10_64_1","first-page":"143","article-title":"Neuroplasticity and predictors of alcohol recovery","volume":"37","author":"Seo D","year":"2015","journal-title":"Alcohol Res"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v2.i3.49"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00579.x"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.109"},{"key":"e_1_2_10_68_1","first-page":"209","article-title":"General Health Questionnaire and Beck Depression Scale as screening methods for psychiatric morbidity among the unemployed","volume":"9","author":"Viinam\u00e4ki H","year":"1995","journal-title":"Eur J Psychiatry"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.07.045"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00886.x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2011.02.009"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.42"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.039"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.13414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.13414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:43:15Z","timestamp":1695490995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.13414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/acer.13414"],"URL":"https:\/\/doi.org\/10.1111\/acer.13414","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,30]]}}}