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Based on the role of neural oscillations in multisensory integration from past studies, we hypothesized that adolescents with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> would show a decrease in oscillatory power during event\u2010related gamma oscillatory activity (30 to 100\u00a0Hz), when compared to typically developing healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>), and that such decrease in oscillatory power would predict behavioral performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured sensory neurophysiology using magnetoencephalography (<jats:styled-content style=\"fixed-case\">MEG<\/jats:styled-content>) during passive auditory, somatosensory, and multisensory (synchronous) stimulation in 19 adolescents (12 to 21\u00a0years) with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> and 23 age\u2010 and gender\u2010matched <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. We employed a cross\u2010hemisphere multisensory paradigm to assess interhemispheric connectivity deficits in children with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Time\u2013frequency analysis of <jats:styled-content style=\"fixed-case\">MEG<\/jats:styled-content> data revealed a significant decrease in gamma oscillatory power for both unisensory and multisensory conditions in the <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> group relative to <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, based on permutation testing of significant group differences. Greater beta oscillatory power (15 to 30\u00a0Hz) was also noted in the <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> group compared to <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> in both unisensory and multisensory conditions. Regression analysis revealed greater predictive power of multisensory oscillations from unisensory oscillations in the <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> group compared to the <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> group. Furthermore, multisensory oscillatory power, for both groups, predicted performance on the Intra\u2010Extradimensional Set Shift Task and the Cambridge Gambling Task.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Altered oscillatory power in the <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> group may reflect a restricted ability to process somatosensory and multisensory stimuli during day\u2010to\u2010day interactions. These alterations in neural oscillations may be associated with the neurobehavioral deficits experienced by adolescents with <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> and may carry over to adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13510","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T05:35:39Z","timestamp":1506317739000},"page":"2173-2184","source":"Crossref","is-referenced-by-count":11,"title":["Altered Neural Oscillations During Multisensory Integration in Adolescents with Fetal Alcohol Spectrum Disorder"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-5746","authenticated-orcid":false,"given":"Alfredo D.","family":"Bola\u00f1os","sequence":"first","affiliation":[{"name":"The Mind Research Network and Lovelace Biomedical and Environmental Research Institute Albuquerque New Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian 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