{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:22:27Z","timestamp":1790180547212,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"am","delay-in-days":335,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01CX000361"],"award-info":[{"award-number":["1I01CX000361"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201012\u20101\u20100497"],"award-info":[{"award-number":["W81XWH\u201012\u20101\u20100497"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AA024935"],"award-info":[{"award-number":["R21 AA024935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK107682"],"award-info":[{"award-number":["R01 DK107682"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AA025208"],"award-info":[{"award-number":["R01 AA025208"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AA021840"],"award-info":[{"award-number":["U01 AA021840"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite that the epidemiological studies on the comorbidity of alcohol misuse and psychiatric disorders have been studied, less is known about the magnitude of these disorders among patients with alcoholic liver disease (<jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>). Our aim was to determine the prevalence of psychiatric and substance use disorders among hospitalized <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content> patients in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized a single\u2010level clinical classification software to identify patients with <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content> and psychiatric\/substance use disorders from the 2011 National Inpatient Sample data. The primary outcome was the prevalence of these disorders among hospitalized patients with <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a074,972) compared to those with chronic liver diseases not caused by alcohol (<jats:italic>n<\/jats:italic>\u00a0=\u00a0350,140) and those without underlying liver diseases (<jats:italic>n<\/jats:italic>\u00a0=\u00a01,447,063).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of adjustment disorder, anxiety disorder, posttraumatic stress disorder, and depression was significantly higher among hospitalized patients with <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content> when compared to those with chronic liver diseases not caused by alcohol (all with <jats:italic>p<\/jats:italic>\u2010values &lt;0.05). Younger age, female gender, and White race were the independent predictors of psychiatric\/substance use disorders among hospitalized patients with <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hospitalized patients with <jats:styled-content style=\"fixed-case\">ALD<\/jats:styled-content> have significantly high prevalence of concomitant psychiatric and substance abuse disorders when compared to those with chronic liver diseases not caused by alcohol and those without underlying liver diseases. Screening and appropriate intervention should be implemented as part of routine clinical care for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13567","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T06:49:09Z","timestamp":1512197349000},"page":"397-402","source":"Crossref","is-referenced-by-count":34,"title":["Concomitant Psychiatric and Nonalcohol\u2010Related Substance Use Disorders Among Hospitalized Patients with Alcoholic Liver Disease in the United States"],"prefix":"10.1111","volume":"42","author":[{"given":"Raxitkumar","family":"Jinjuvadia","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Henry Ford Hospital Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetna","family":"Jinjuvadia","sequence":"additional","affiliation":[{"name":"Division of Pulmonology and Critical Care Medicine Department of Medicine Wayne State University Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimpitcha","family":"Puangsricharoen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\/Hepatology Indiana University School of Medicine Indianapolis Indiana"},{"name":"Chulalongkorn University Faculty of Medicine Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga","family":"Chalasani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\/Hepatology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0214","authenticated-orcid":false,"given":"David W.","family":"Crabb","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\/Hepatology Indiana University School of Medicine Indianapolis Indiana"},{"name":"Department of Biochemistry and Molecular Biology Indiana University School of Medicine Indianapolis Indiana"},{"name":"Eskenazi Health Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-8123","authenticated-orcid":false,"given":"Suthat","family":"Liangpunsakul","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology\/Hepatology Indiana University School of Medicine Indianapolis Indiana"},{"name":"Department of Biochemistry and Molecular Biology Indiana University School of Medicine Indianapolis Indiana"},{"name":"Roudebush Veterans Administration Medical Center Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v3.i5.108"},{"key":"e_1_2_8_3_1","unstructured":"Centers for Disease Control and Prevention(2015)International Classification of Diseases Ninth Revision Clinical Modification (ICD\u20109\u2010CM).National Center for Health Statistics Atlanta GA. 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