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However,<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>combined with<jats:styled-content style=\"fixed-case\">BUP<\/jats:styled-content>(10.0\u00a0mg\/kg<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>\u00a0+\u00a010.0\u00a0mg\/kg<jats:styled-content style=\"fixed-case\">BUP<\/jats:styled-content>) and given as a single medication significantly reduced alcohol consumption throughout prolonged treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combining low doses of<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">BUP<\/jats:styled-content>, each of which is ineffective when given alone, increases the efficacy of the medication. Low drug doses circumvent the problem of negative side effects that can occur with higher doses of either drug. A reduction in side effects can facilitate patient compliance and improve clinical outcomes for alcoholics and heavy drinkers who want to reduce their alcohol intake. The results, together with those from our prior studies, demonstrate the strength of a combinatorial pharmacotherapeutic approach to the treatment of alcohol use disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13577","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T14:22:42Z","timestamp":1512829362000},"page":"571-577","source":"Crossref","is-referenced-by-count":12,"title":["Co\u2010Administration of Low\u2010Dose Naltrexone and Bupropion Reduces Alcohol Drinking in Alcohol\u2010Preferring (P) Rats"],"prefix":"10.1111","volume":"42","author":[{"given":"Emily R.","family":"Nicholson","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine (ERN, JED, JCF) Indianapolis Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian E.","family":"Dilley","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine (ERN, JED, JCF) Indianapolis 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