{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:25:27Z","timestamp":1789907127832,"version":"4.0.1"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T00:00:00Z","timestamp":1544745600000},"content-version":"am","delay-in-days":319,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000179","name":"Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA024112"],"award-info":[{"award-number":["R01AA024112"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Aversion to the orosensory properties of concentrated ethanol (EtOH) solutions is often cited as a primary barrier to initiation of drinking and may contribute to abstention. These aversive properties include gustatory processes which encompass both bitter\u2010like taste qualities and trigeminal\u2010mediated irritation. Chronic intermittent EtOH access (<jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content>) results in substantial and persistent increases in EtOH consumption, but the degree to which this facilitation involves sensory responding to EtOH and other bitter stimuli is currently undetermined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Long\u2010Evans rats were given brief\u2010access licking tests designed to examine the immediate, taste\u2010guided assessment of the palatability of EtOH and quinine solutions. Rats were assessed once in a na\u00efve state and again following previous brief\u2010access exposure, or following 4\u00a0weeks of <jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content>. The relationship between the sensitivity to the aversive orosensory properties of EtOH and quinine following EtOH access and the impact of antecedent quinine exposure on the acceptance of EtOH were determined in 2 parallel studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both brief access to EtOH and 4\u2010week <jats:styled-content style=\"fixed-case\">CIA<\/jats:styled-content> resulted in substantial rightward shifts in the concentration\u2013response function of brief\u2010access EtOH licking, indicating that EtOH exposure increased acceptance of the taste of EtOH. The initial sensitivity to the aversive orosensory properties of EtOH and quinine was positively correlated in na\u00efve rats, such that rats that were initially more accepting of quinine were also more accepting of EtOH. Rats that sampled quinine immediately prior to tasting EtOH exhibited successive positive contrast in that they were more accepting of highly concentrated EtOH, relative to a water\u2010control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased EtOH acceptance following exposure is, at least in part, facilitated by a decrease in its aversive sensory properties. Both long\u2010 and short\u2010term access increase the palatability of the taste of EtOH in brief\u2010access licking tests. Moreover, the sensitivity to the bitterness of quinine was predictive of acceptance of EtOH indicating some commonality in the sensory mechanisms that mediate the initial acceptance of the 2 stimuli. Accordingly, immediate prior exposure to quinine results in increased acceptance of EtOH, suggesting that successive positive contrast between oral stimuli may contribute to increased alcohol consumption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13581","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T19:32:35Z","timestamp":1513279955000},"page":"589-602","source":"Crossref","is-referenced-by-count":23,"title":["Brief Exposures to the Taste of Ethanol (EtOH) and Quinine Promote Subsequent Acceptance of EtOH in a Paradigm that Minimizes Postingestive Consequences"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-1885","authenticated-orcid":false,"given":"Gregory C.","family":"Loney","sequence":"first","affiliation":[{"name":"Department of Psychology State University of New York at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Psychology State University of New York at Buffalo Buffalo New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(03)00075-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12527"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000051021.99641.19"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(94)90361-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01759B"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(92)90036-A"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00309.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00309.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00113.2009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00415.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724990143000261"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01328.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00196.2010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21273"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00131-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(86)90071-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjs063"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000145789.55183.D4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23894"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13089"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1986.tb05124.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00108.2017"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03208702"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00117-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjq132"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(96)00215-7"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01241.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/appe.1993.1032"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10665.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00909.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(90)90071-J"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.103.6.1318"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/18.5.509"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.10.004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1330-9"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00097.2004"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00700.2005"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00580.2011"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(79)90270-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6036-11.2012"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556219971678"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00397-8"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10254-005-0041-0"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v17n01_06"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(95)01104-7"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12078-015-9196-5"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.01.017"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810184106"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(82)90259-1"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjl024"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(99)00149-0"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4661-6_4"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00753.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00345.2006"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/appe.2000.0372"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.07.014"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21178"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21430"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.04.019"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105232"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0602-852"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809804106"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.99.2.290"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.13581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.13581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.13581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/acer.13581","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.13581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:00:26Z","timestamp":1695618026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.13581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,29]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/acer.13581"],"URL":"https:\/\/doi.org\/10.1111\/acer.13581","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,29]]}}}