{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:58Z","timestamp":1787013778596,"version":"build-2736575974"},"reference-count":79,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA021744"],"award-info":[{"award-number":["R01AA021744"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","award":["UL1RR033176"],"award-info":[{"award-number":["UL1RR033176"]}],"id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Genetic variation in the endogenous opioid system has been identified as 1 potential source of individual variability in naltrexone treatment outcomes. The majority of naltrexone pharmacogenetic studies have focused on a particular single nucleotide polymorphism (SNP) of the mu\u2010opioid receptor gene (\n                      <jats:italic>OPRM1<\/jats:italic>\n                      ; rs1799971; commonly known as the Asn40Asp SNP) in Caucasian samples with decidedly mixed results. The goal of this study was to test the pharmacogenetic effects of naltrexone on subjective response to alcohol and self\u2010administration of alcohol in individuals of East Asian descent. We hypothesized that naltrexone, compared with placebo, would potentiate the aversive and sedative effects of alcohol and reduce alcohol self\u2010administration to a greater extent in Asp40 carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a077; Asn40Asn,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a029; Asn40Asp,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a034, and Asp40Asp,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a014) completed 2 double\u2010blinded and counterbalanced experimental sessions: one after taking naltrexone (50\u00a0mg\/d) for 5\u00a0days and one after taking matched placebo for 5\u00a0days. In each experimental session, participants received a priming dose of intravenous alcohol up to the breath alcohol concentration target of 0.06\u00a0g\/dl which was immediately followed by an alcohol self\u2010administration period (1\u00a0hour).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were no pharmacogenetic effects observed for alcohol\u2010induced stimulation, sedation, craving for alcohol, or alcohol self\u2010administration in the laboratory. During the self\u2010administration period, Asp40 carriers consumed fewer drinks and had a longer latency to first drink as compared to Asn40 homozygotes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings in East Asians add to the mixed literature on naltrexone pharmacogenetics from predominantly Caucasian samples and highlight the complexity of these effects and their overall limited replicability. It is plausible that a consistent pharmacogenetic effect in tightly controlled preclinical and experimental medicine models \u201cfades\u201d in more complex and heterogeneous settings and samples.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.13586","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T11:02:46Z","timestamp":1513681366000},"page":"613-623","source":"Crossref","is-referenced-by-count":15,"title":["Pharmacogenetic Effects of Naltrexone in Individuals of East Asian Descent: Human Laboratory Findings from a Randomized Trial"],"prefix":"10.1111","volume":"42","author":[{"given":"Lara A.","family":"Ray","sequence":"first","affiliation":[{"name":"Department of Psychology University of California, Los Angeles Los Angeles California"},{"name":"Department of Psychiatry and Biobehavioral Sciences University of California, Los Angeles Los Angeles 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