{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:08:47Z","timestamp":1777367327929,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AA006059"],"award-info":[{"award-number":["R01 AA006059"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AA019969"],"award-info":[{"award-number":["U01 AA019969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Disturbances in sleep architecture, especially reductions in slow\u2010wave sleep (SWS), are symptoms commonly observed in individuals with alcohol use disorders. Recent clinical trials have demonstrated that the anticonvulsant and analgesic drug gabapentin may have therapeutic value in normalizing sleep quality in recovering alcoholics. However, the brain mechanisms underlying this improvement in sleep following gabapentin treatment remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, adult Wistar rats were exposed to 8\u00a0weeks of chronic intermittent ethanol [EtOH] vapor (blood EtOH concentrations averaged 128.2\u00a0\u00b1\u00a017.4\u00a0mg\/dl) or control conditions and then withdrawn. Sleep electroencephalograms [EEGs] and event\u2010related oscillations (EROs) were evaluated at baseline prior to EtOH exposure and 24\u00a0hours following EtOH withdrawal. Four weeks following EtOH withdrawal the effects of saline and 2 doses of gabapentin (30, 120\u00a0mg\/kg), on EROs and sleep EEGs, were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As compared to baseline, 24\u00a0hours following alcohol withdrawal SWS became fragmented as indexed by a significant increase in the number and a decrease in the duration of SWS episodes. Compared to controls, the EtOH\u2010exposed group had more ERO energy in the beta frequency band in the parietal cortex. Gabapentin induced a dose\u2010dependent decrease in the latency to the first SWS episode, and a reduction in sleep fragmentation. Gabapentin also produced a dose\u2010dependent increase in ERO energy in the control group that was significantly attenuated in the EtOH\u2010exposed group in the theta, and beta frequency bands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, these studies suggest that gabapentin can reverse some of the alcohol\u2010induced sleep and EEG deficits but does not eliminate all of the enduring brain effects of EtOH exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13588","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T14:06:35Z","timestamp":1514556395000},"page":"624-633","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Gabapentin on Sleep and Event\u2010Related Oscillations (EROs) in Rats Exposed to Chronic Intermittent Ethanol Vapor and Protracted 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