{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:37:56Z","timestamp":1790415476543,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA015407"],"award-info":[{"award-number":["AA015407"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA020051"],"award-info":[{"award-number":["AA020051"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fetal ethanol (EtOH) exposure can damage the developing central nervous system and lead to cognitive and behavioral deficits, known as fetal alcohol spectrum disorders (<jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content>). EtOH exposure to mouse pups during early neonatal development was used as a model of EtOH exposure that overlaps the human third\u2010trimester \u201cbrain growth spurt\u201d\u2014a model that has been widely used to study <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6 male and female mice were exposed to EtOH (4\u00a0g\/kg\/d) on postnatal days (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) 4 to 10 by oral intubation. Intubated and nontreated controls were also included. Behavioral testing of the offspring, including open field, elevated plus maze, and Morris water maze, was performed on <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> 20 to 45.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EtOH exposure during <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> 4 to 10 resulted in hyperactivity and deficits in learning and memory in young mice with no apparent sex differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on these data, this neonatal intubation mouse model may be useful for future mechanistic and genetic studies of <jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content> and for screening of novel therapeutic agents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13598","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T10:12:40Z","timestamp":1516097560000},"page":"743-750","source":"Crossref","is-referenced-by-count":18,"title":["Neonatal Ethanol Exposure Causes Behavioral Deficits in Young Mice"],"prefix":"10.1111","volume":"42","author":[{"given":"Wenhua","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Nutritional Sciences University of Kentucky College of Medicine Lexington Kentucky"},{"name":"Department of Neurology Affiliated Provincial Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Hawkey","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Kentucky College of Art &amp; Sciences Lexington 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