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In this study, we measured the effects of apremilast on other behaviors that are correlated with EtOH consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effects of apremilast (20\u00a0mg\/kg) on the following behaviors were studied in male and female C57BL\/6J mice: locomotor response to a novel situation; EtOH\u2010 and lithium chloride (LiCl)\u2010induced conditioned taste aversion (CTA) to saccharin; conditioned place preference (CPP) and conditioned place avoidance (CPA) to EtOH; severity of handling\u2010induced convulsions after EtOH administration; EtOH\u2010induced anxiolytic\u2010like behavior in the elevated plus maze; duration of EtOH\u2010induced loss of righting reflex (LORR); recovery from EtOH\u2010induced motor impairment on the rotarod; and acute functional tolerance (AFT) to EtOH's ataxic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apremilast did not change the acquisition of EtOH\u2010induced CPP, severity of acute withdrawal from EtOH, or EtOH's anxiolytic\u2010like effect. Apremilast did not alter the extinction of EtOH\u2010 or LiCl\u2010induced CTA, but may interfere with acquisition of CTA to EtOH. Apremilast increased the acquisition of CPA to EtOH, reduced locomotor responses to a novel situation, and prolonged the duration of LORR and the recovery from acute motor incoordination induced by EtOH. The longer recovery from the ataxic effect may be attributed to reduced development of AFT to EtOH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that apremilast increases the duration of EtOH intoxication by reducing AFT. Apremilast also reduces some aspects of general reward and increases EtOH's aversive properties, which might also contribute to its ability to reduce EtOH drinking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13615","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T14:02:38Z","timestamp":1519308158000},"page":"939-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Apremilast Alters Behavioral Responses to Ethanol in Mice: II. 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