{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:45:52Z","timestamp":1740138352826,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to investigate the effect of excessive alcohol consumption on heart reflected by various echocardiographic parameters according to the presence or absence of flushing reaction that might reflect acetaldehyde metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 854 Korean men without significant cardiovascular diseases who underwent echocardiography and participated in the Korean Healthy Twin Study were used as subjects of this study. These subjects were classified into 3 categories: nondrinker, moderate drinker (\u2264196\u00a0g\/wk), and heavy drinker (&gt;196\u00a0g\/wk) within 2 strata of flushing reaction to alcohol drinking. Association between echocardiographic measurements and categories of the amount of alcohol consumption considering flushing reaction were evaluated using mixed linear regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of flushers among drinkers was 39.5% (278 of 703). In stratified analysis by flushing reaction, nonflushers showed significantly higher left ventricular mass index (<jats:italic>\u03b2<\/jats:italic>: 4.605; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.966, 8.243) and significantly lower ratio of peak early diastolic velocities (<jats:italic>E<\/jats:italic> peak) over peak late diastolic velocities of mitral inflow (<jats:italic>\u03b2<\/jats:italic>: \u22120.103; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.198, \u22120.008) in heavy drinkers compared to nondrinkers. Flushers showed significantly higher left atrial (LA) volume index (<jats:italic>\u03b2<\/jats:italic>: 2.712; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.456, 4.968) in heavy drinkers and significantly lower ratio of <jats:italic>E<\/jats:italic> peak over the peak early diastolic mitral annular velocities (<jats:italic>\u03b2<\/jats:italic>: \u22120.493; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22120.902, \u22120.085) in moderate drinkers compared to nondrinkers. However, the interaction according to flushing reaction was only statistically significant for the association between alcohol consumption and LA volume index (<jats:italic>p<\/jats:italic> for interaction\u00a0=\u00a00.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alcohol consumption is associated with changes in cardiac structure and function. Such association might be influenced by acetaldehyde metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13622","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T05:02:56Z","timestamp":1520658176000},"page":"897-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Excessive Alcohol Consumption and Echocardiographic Parameters According to the Presence of Flushing Reaction in Korean Men: A Community\u2010Based Study"],"prefix":"10.1111","volume":"42","author":[{"given":"Hyeonyoung","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Family Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-5563","authenticated-orcid":false,"given":"Yun\u2010Mi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Chol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Imaging Center Cardiac and Vascular Center Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Imaging Center Cardiac and Vascular Center Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joohon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health and Institute of Health Environment Seoul National University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2816-554X","authenticated-orcid":false,"given":"Kayoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Busan Paik Hospital School of Medicine Inje University Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq426"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01530.x"},{"key":"e_1_2_6_4_1","first-page":"273","article-title":"Alcohol deranges hepatic lipid metabolism via altered transcriptional regulation","volume":"115","author":"Crabb DW","year":"2004","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2003327"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-008-0017-z"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002846"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.07.013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i8.771"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.07.014"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32833833a3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/35.4.331"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.46.5.545"},{"key":"e_1_2_6_15_1","unstructured":"Korean Statistical Information Service(2012)Korean Population Census 2010. 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