{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:58Z","timestamp":1787013778105,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R34 AA020853"],"award-info":[{"award-number":["R34 AA020853"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preventing alcohol\u2010exposed pregnancies (AEPs) could reduce the incidence of fetal alcohol spectrum disorders. Previous face\u2010to\u2010face interventions significantly reduced risk for AEP, but a scalable intervention is needed to reach more women at risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study compared a 6 Core automated, interactive, and tailored Internet intervention, the Contraception and Alcohol Risk Reduction Internet Intervention (CARRII), to a static patient education (PE) website for its effect on AEP risk. Participants were recruited online to a pilot randomized clinical trial (RCT) with baseline, 9\u00a0weeks posttreatment, and 6\u2010month (6\u2010M) follow\u2010up assessments. Seventy\u2010one women completed online questionnaires and telephone interviews and were randomized to CARRII (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a036) or PE (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a035). Primary outcomes were rates of risky drinking, unprotected sex episodes, and AEP risk, collected from online prospective diaries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CARRII participants showed significant reductions in rate of unprotected sex from pretreatment (88.9%) to posttreatment (70.6%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.04) and to 6\u2010M follow\u2010up (51.5%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001); rate of risky drinking from pretreatment (75.0%) to posttreatment (50.0%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.02), but insignificant change from pretreatment to 6\u2010M follow\u2010up (57.6%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.09); and rate of AEP risk from pretreatment (66.7%) to posttreatment (32.4%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) and to 6\u2010M follow\u2010up (30.3%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005). PE participants demonstrated no significant changes on all 3 variables across all time points. Intent\u2010to\u2010treat group\u2010by\u2010time tests were not significant, but power was limited by missing diaries. Over 72% of CARRII participants completed all 6 Cores. Exploratory analyses suggest that higher program utilization is related to change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data show that CARRII was acceptable, feasible, promising to reduce AEP risk, and merits further testing in a fully powered RCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.13635","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T11:59:29Z","timestamp":1525867169000},"page":"1132-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Pilot RCT of an Internet Intervention to Reduce the Risk of Alcohol\u2010Exposed Pregnancy"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8115-2548","authenticated-orcid":false,"given":"Karen","family":"Ingersoll","sequence":"first","affiliation":[{"name":"Center for Behavioral Health and Technology University of Virginia School of Medicine Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Frederick","sequence":"additional","affiliation":[{"name":"Center for Behavioral Health and Technology University of Virginia School of Medicine Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"MacDonnell","sequence":"additional","affiliation":[{"name":"Center for Behavioral Health and Technology University of Virginia School of Medicine Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Ritterband","sequence":"additional","affiliation":[{"name":"Center for Behavioral Health and Technology University of Virginia School of Medicine Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Lord","sequence":"additional","affiliation":[{"name":"Center for Behavioral Health and Technology University of Virginia School of Medicine Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brogan","family":"Jones","sequence":"additional","affiliation":[{"name":"Center for Behavioral Health and Technology University of Virginia School of Medicine Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Truwit","sequence":"additional","affiliation":[{"name":"Center for Behavioral Health and Technology University of Virginia School of Medicine Charlottesville Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2010.10.008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2016.06.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1940-0640-8-1"},{"key":"e_1_2_6_5_1","first-page":"1466","article-title":"Web\u2010based screening and brief intervention for unhealthy alcohol use","volume":"7","author":"Bertholet N","year":"2011","journal-title":"Rev Med Suisse"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-010-9308-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2017.08.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9165-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/tmj.2012.0247"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1506575"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(99)00059-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/152460999319048"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2006.08.028"},{"key":"e_1_2_6_14_1","unstructured":"FoxS FallowsD(2003)Internet Health Resources(the Pew Research Trust). 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