{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:57:32Z","timestamp":1791647852942,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AA014809"],"award-info":[{"award-number":["U01AA014809"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24AA014815"],"award-info":[{"award-number":["U24AA014815"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01014834"],"award-info":[{"award-number":["U01014834"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01AA017122"],"award-info":[{"award-number":["U01AA017122"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24AA014811"],"award-info":[{"award-number":["U24AA014811"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Since the 1970s, a range of facial, neurostructural, and neurocognitive adverse effects have been shown to be associated with prenatal alcohol exposure. Typically, these effects are studied individually and not in combination. Our objective is to improve the understanding of the teratogenic effects of prenatal alcohol exposure by simultaneously considering face\u2013brain morphology and neurocognitive measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants were categorized as control (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a047), fetal alcohol syndrome (FAS,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a022), or heavily exposed (HE) prenatally, but not eligible for a FAS diagnosis (HE,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a050). Structural brain MRI images and high\u2010resolution 3D facial images were analyzed using dense surface models of features of the face and surface shape of the corpus callosum (CC) and caudate nucleus (CN). Asymmetry of the CN was evaluated for correlations with neurocognitive measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>(i) Facial growth delineations for FAS, HE, and controls are replicated for the CN and the CC. (ii) Concordance of clinical diagnosis and face\u2010based control\u2013FAS discrimination improves when the latter is combined with specific brain regions. In particular, midline facial regions discriminate better when combined with a midsagittal profile of the CC. (iii) A subset of HE individuals was identified with FAS\u2010like CN dysmorphism. The average of this HE subset was FAS\u2010like in its facial dysmorphism. (iv) Right\u2013left asymmetry found in the CNs of controls is not apparent for FAS, is diminished for HE, and correlates with neurocognitive measures in the combined FAS and HE population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Shape analysis which combines facial regions with the CN, and with the CC, better identify those with FAS. CN asymmetry was reduced for FAS compared to controls and is strongly associated with general cognitive ability, verbal learning, and recall in those with prenatal alcohol exposure. This study further extends the brain\u2013behavior relationships known to be vulnerable to alcohol teratogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.13820","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T11:25:36Z","timestamp":1529753136000},"page":"1769-1782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Combined Face\u2013Brain Morphology and Associated Neurocognitive Correlates in Fetal Alcohol Spectrum Disorders"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5538-8431","authenticated-orcid":false,"given":"Michael","family":"Suttie","sequence":"first","affiliation":[{"name":"Nuffield Department of Women's and Reproductive Health  University of Oxford Oxford United Kingdom"},{"name":"Big Data Institute  University of Oxford Oxford United 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