{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:04:36Z","timestamp":1778565876758,"version":"3.51.4"},"reference-count":69,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P01AA019072"],"award-info":[{"award-number":["P01AA019072"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol use disorder (<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>) is prevalent among individuals diagnosed with human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>), and both <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and alcohol use have been shown to negatively affect the integrity of white matter pathways in the brain. Behavioral, functional, and anatomical impairments have been linked independently to <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and alcohol use, and these impairments have bases in specific frontally mediated pathways within the brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Magnetic resonance imaging data were acquired for 37 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>+ participants without dementia or hepatitis C. Imaging data were processed through the FreeSurfer and Tra<jats:styled-content style=\"fixed-case\">CULA<\/jats:styled-content> pipelines to obtain 4 bilateral frontal white matter tracts for each participant. Diffusion metrics of white matter integrity along the highest probability pathway for each tract were analyzed with respect to demographics, disease\u2010specific variables, and reported substance use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly increased axial diffusivity (decreased axonal integrity) and a trending increase in mean diffusivity were observed along the anterior thalamic radiation (<jats:styled-content style=\"fixed-case\">ATR<\/jats:styled-content>) in participants with a history of <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>. A diagnosis of <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content> explained over 36% of the variance in diffusivity along the ATR overall when accounting for clinical variables including nadir <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 and age\u2010adjusted <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection length.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides evidence of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related associations between alcohol use and indicators of axonal integrity loss along the <jats:styled-content style=\"fixed-case\">ATR<\/jats:styled-content>, a frontal pathway involved in the inhibition of addictive or unwanted behaviors. Reduced axonal integrity of this pathway was greatest in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>+ participants with an <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>, even when considering the effect of age\u2010adjusted disease length and severity (nadir <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4). This finding implicates a potential biological mechanism linking reduced integrity of frontal white matter to the high prevalence of <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content> in an <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>+ population without dementia or hepatitis C.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13823","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T13:20:15Z","timestamp":1530278415000},"page":"1640-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Impact of Alcohol Use on Frontal White Matter in HIV"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8184-7187","authenticated-orcid":false,"given":"Joseph M.","family":"Gullett","sequence":"first","affiliation":[{"name":"Center for Cognitive Aging and Memory  McKnight Brain Institute University of Florida Gainesville Florida"},{"name":"Department of Clinical and Health Psychology  University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damon G.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Center for Cognitive Aging and Memory  McKnight Brain Institute University of Florida Gainesville Florida"},{"name":"Department of Clinical and Health Psychology  University of Florida Gainesville Florida"},{"name":"Brain Rehabilitation Research Center  Malcom Randall VA Medical Center Gainesville Florida"},{"name":"Department of Neurology  University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Porges","sequence":"additional","affiliation":[{"name":"Center for Cognitive Aging and Memory  McKnight Brain Institute University of Florida Gainesville Florida"},{"name":"Department of Clinical and Health Psychology  University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Woods","sequence":"additional","affiliation":[{"name":"Center for Cognitive Aging and Memory  McKnight Brain Institute University of Florida Gainesville Florida"},{"name":"Department of Clinical and Health Psychology  University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake","family":"Rieke","sequence":"additional","affiliation":[{"name":"Brain Rehabilitation Research Center  Malcom Randall VA Medical Center Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center  Mark and Mary Stevens Neuroimaging and Informatics Institute USC Keck School of Medicine Marina del Rey California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center  Mark and Mary Stevens Neuroimaging and Informatics Institute USC Keck School of Medicine Marina del Rey California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia M.","family":"Nir","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center  Mark and Mary Stevens Neuroimaging and Informatics Institute USC Keck School of Medicine Marina del Rey California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Tashima","sequence":"additional","affiliation":[{"name":"The Miriam Hospital  Alpert College of Medicine Brown University Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-8847","authenticated-orcid":false,"given":"Ronald A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Center for Cognitive Aging and Memory  McKnight Brain Institute University of Florida Gainesville Florida"},{"name":"Department of Clinical and Health Psychology  University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10101284"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.782"},{"key":"e_1_2_6_5_1","unstructured":"1958 John Wiley New York G Blom Statistical Estimates and Transformed Beta Variables"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-008-9143-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00277.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550280903552420"},{"key":"e_1_2_6_10_1","first-page":"739","article-title":"Detection of multiple pathways in the spinal cord white matter using q\u2010ball imaging","volume":"42","author":"Cohen\u2010Adad J","year":"2008","journal-title":"Biomed Imaging Nano Macro"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb38127.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0807-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.044"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.12.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92786-2"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.68.1.134"},{"key":"e_1_2_6_17_1","first-page":"558","article-title":"Cortical gray matter loss in treatment\u2010na\u00efve alcohol dependent individuals","volume":"26","author":"Fein G","year":"2002","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_6_18_1","unstructured":"FirstMB SpitzerRL GibbonM WilliamsJBW(2007)Structured Clinical Interview for DSM\u2010IV\u2010TR Axis I Disorders\u2013Non\u2010Patient Edition (SCID\u2010I\/NP 1\/2007 revision). Biometrics Research Department New York State Psychiatric Institute New York NY."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2002.63.179"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.4.345"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-011-0055-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.1.141"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v27n02_02"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1991.tb00540.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1543"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.081"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000390"},{"key":"e_1_2_6_30_1","first-page":"178","article-title":"Color atlas of human anatomy, in Nervous System and Sensory Organs","volume":"3","author":"Kahle W","year":"2003","journal-title":"Thieme"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00308-3"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294228"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2009.11.005"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.1.104"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ics.2006.04.006"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1076"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02599920"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/09595238880000201"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3647-07.2007"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073021"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.02.006"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.095869"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.05.067"},{"key":"e_1_2_6_44_1","first-page":"288","article-title":"Effects of alcohol and HIV infection on the central nervous system","volume":"25","author":"Meyerhoff DJ","year":"2001","journal-title":"Alcohol Res Health"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/36.5.357"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26623"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-010-0071-3"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20411"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462991914654"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl242"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832e77fe"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0765"},{"key":"e_1_2_6_53_1","unstructured":"2016 R Found Stat Comput Vienna Austria R Development Core Team R: A Language and Environment for Statistical Computing"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.015"},{"key":"e_1_2_6_55_1","first-page":"247","article-title":"Focus on the brain: HIV infection and alcoholism: comorbidity effects on brain structure and function","volume":"33","author":"Rosenbloom MJ","year":"2010","journal-title":"Alcohol Res Health"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-015-0386-3"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02342.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.07.005"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.01.028"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2015.76.296"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-009-9104-3"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000052584.05305.98"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20774"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-003-1114-x"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.17705\/1CAIS.02804"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01001354"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13211"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00023"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.027"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-012-0135-9"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.13823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.13823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T22:35:48Z","timestamp":1694990148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.13823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,16]]},"references-count":69,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/acer.13823"],"URL":"https:\/\/doi.org\/10.1111\/acer.13823","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,16]]},"assertion":[{"value":"2018-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}