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Individuals with alcohol dependence and substance abuse have high prevalence of <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>. However, the prevalence of <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content> in heavy drinkers with alcoholic hepatitis (AH) is not known.The study's aim was to determine the prevalence of PTSD in heavy drinkers with and without AH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We screened for <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content> using the Primary Care\u2010<jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content> questionnaire among heavy drinkers with (<jats:italic>n<\/jats:italic>\u00a0=\u00a0115) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a064) AH participating in a multicenter observational study in which participants were followed up to 12\u00a0months following their enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content> in heavy drinkers with AH was 34% and was not different from heavy drinking controls without liver disease (34%). In the entire group screened for <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>, the presence of <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content> was associated with higher alcohol consumption as reported by average drinks per last 30\u00a0days and average grams of alcohol consumed per day (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.047 for both tests), but not associated with relapse of heavy drinking or mortality. Similarly, patients with AH and <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content> did not have higher relapse rate or higher mortality compared to patients with AH but no <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to previously reported prevalence in general population, heavy drinking individuals with or without AH have significantly higher prevalence of <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content>. However, <jats:styled-content style=\"fixed-case\">PTSD<\/jats:styled-content> was not associated with higher relapse rate or higher mortality in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13862","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T10:49:58Z","timestamp":1533638998000},"page":"1933-1938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Posttraumatic Stress Disorder in Patients with Heavy Alcohol Consumption and Alcoholic Hepatitis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1993-5223","authenticated-orcid":false,"given":"Niharika","family":"Samala","sequence":"first","affiliation":[{"name":"Department of Medicine  Division of Gastroenterology and Hepatology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer G.","family":"Lourens","sequence":"additional","affiliation":[{"name":"Department of Biostatistics  Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine  Division of Gastroenterology and Hepatology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Medicine  Division of Gastroenterology and Hepatology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun J.","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Department of Medicine  Division of Gastroenterology Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0214","authenticated-orcid":false,"given":"David W.","family":"Crabb","sequence":"additional","affiliation":[{"name":"Department of Medicine  Division of Gastroenterology and Hepatology Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics  Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Radaeva","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism  Bethesda 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