{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:20:28Z","timestamp":1790630428335,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"INRS-Institut Armand-Frappier"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreatitis is an increasingly common clinical condition that causes significant morbidity and mortality. Cannabis use causes conflicting effects on pancreatitis development. We conducted a larger and more detailed assessment of the impact of cannabis use on pancreatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data from 2012 to 2014 of the Healthcare Cost and Utilization Project\u2014Nationwide Inpatient Sample discharge records of patients 18\u00a0years and older. We used the International Classification of Disease, Ninth Edition codes, to identify 3 populations: those with gallstones (379,125); abusive alcohol drinkers (762,356); and non\u2010alcohol\u2010non\u2010gallstones users (15,255,464). Each study population was matched for cannabis use record by age, race, and gender, to records without cannabis use. The estimation of the adjusted odds ratio (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>) of having acute and chronic pancreatitis (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) made use of conditional logistic models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Concomitant cannabis and abusive alcohol use were associated with reduced incidence of <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 0.50 [0.48 to 0.53] and 0.77 [0.71 to 0.84]). Strikingly, for individuals with gallstones, additional cannabis use did not impact the incidence of <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. Among non\u2010alcohol\u2010non\u2010gallstones users, cannabis use was associated with increased incidence of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, but not <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> (1.28 [1.14 to 1.44] and 0.93 [0.86 to 1.01]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest a reduced incidence of only alcohol\u2010associated pancreatitis with cannabis use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13929","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T15:07:21Z","timestamp":1545318441000},"page":"277-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Reduced Risk of Alcohol\u2010Induced Pancreatitis With Cannabis Use"],"prefix":"10.1111","volume":"43","author":[{"given":"Adeyinka 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