{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:46:16Z","timestamp":1772833576400,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T00:00:00Z","timestamp":1545609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012943","name":"Institut national de la recherche scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alcoholic gastritis, a superficial erosive disease of the stomach, is a common manifestation of risky alcohol use. In contrast, cannabis which is frequently co\u2010used with alcohol suppresses gastric acidity and might counteract the deleterious effect of alcohol on the gastric mucosa. However, no clinical study has examined the impact of cannabis use on the development of alcoholic gastritis among risky alcohol users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed hospital discharge records of adults (age \u2265 18\u00a0years), from 2014 of the Nationwide Inpatient Sample, with a diagnosis of risky alcohol use (<jats:italic>n<\/jats:italic>\u00a0=\u00a0316,916). We used a propensity\u2010based matching algorithm to match cannabis users to nonusers on 1:1 ratio (30,713: 30,713). We then measured the adjusted relative risk (<jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>) for having alcoholic gastritis using conditional Poisson regression models with generalized estimating equations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study revealed that among risky alcohol users, cannabis co\u2010users have a lower prevalence of alcoholic gastritis compared to noncannabis users (1,289 [1,169 to 1,421] vs. 1,723 [1,583 to 1,875] per 100,000 hospitalizations for risky alcohol use), resulting in a 25% decreased probability of alcoholic gastritis (<jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>: 0.75 [0.66 to 0.85]; <jats:italic>p<\/jats:italic>\u2010value &lt;0.0001). Furthermore, dependent cannabis usage resulted in a lower prevalence of alcoholic gastritis when compared to both nondependent cannabis users (0.72 [0.52 to 0.99]) and to noncannabis users (0.56 [0.41 to 0.76]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We reveal that risky alcohol drinking combined with cannabis use is associated with reduced prevalence of alcohol\u2010associated gastritis in patients. Given increased cannabis legislation globally, understanding whether and how the specific ingredients in cannabis plant extract can be used in the treatment of alcoholic gastritis is paramount. In this regard, further molecular mechanistic studies are needed to delineate the mechanisms of our novel findings not only for alcoholic gastritis but also for gastritis from other causes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13930","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T14:55:15Z","timestamp":1544453715000},"page":"270-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reduced Prevalence of Alcoholic Gastritis in Hospitalized Individuals Who Consume Cannabis"],"prefix":"10.1111","volume":"43","author":[{"given":"Adeyinka Charles","family":"Adejumo","sequence":"first","affiliation":[{"name":"North Shore Medical Center Salem Massachusetts"},{"name":"Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"INRS\u2010Institut Armand\u2010Frappier Institut National de la Recherche Scientifique Laval Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olalekan","family":"Akanbi","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine University of Kentucky College of Medicine Lexington Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelechi Lauretta","family":"Adejumo","sequence":"additional","affiliation":[{"name":"School of Public Health University of Massachusetts Lowell Lowell Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-0617","authenticated-orcid":false,"given":"Terence Ndonyi","family":"Bukong","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"},{"name":"INRS\u2010Institut Armand\u2010Frappier Institut National de la Recherche Scientifique Laval Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2016.04.021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-015-2090-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704625"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2004.09.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13696"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176416"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045125312457586"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03347.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.6.843"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900135"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs114"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1495"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2016.0001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4172\/2327-5162.1000231"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090167"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000779"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160303110150"},{"key":"e_1_2_9_19_1","unstructured":"Hammill B(2015)GMATCH SAS macro: computerized matching of cases to controls using the greedy matching algorithm with a fixed number of controls per case. 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