{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:45:13Z","timestamp":1769075113173,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AA023669"],"award-info":[{"award-number":["R21AA023669"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DA007272"],"award-info":[{"award-number":["T32 DA007272"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32DA024635"],"award-info":[{"award-number":["T32DA024635"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Brief interventions have empirical support for acutely reducing alcohol use among non\u2013treatment\u2010seeking heavy drinkers. Neuroimaging techniques allow for the examination of the neurobiological effect of behavioral interventions, probing brain systems putatively involved in clinical response to treatment. Few studies have prospectively evaluated whether psychosocial interventions attenuate neural cue reactivity that in turn reduces drinking in the same population. This study aimed to examine the effect of a brief intervention on drinking outcomes, neural alcohol cue reactivity, and the ability of neural alcohol cue reactivity to prospectively predict drinking outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2013treatment\u2010seeking heavy drinking participants were randomized to receive a brief interview intervention (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) or an attention\u2010matched control (<jats:italic>n<\/jats:italic>\u00a0=\u00a024). Immediately following the intervention or control, participants underwent a functional magnetic resonance imaging scan comprised of the alcohol taste cues paradigm. Four weeks after the intervention (or control), participants completed a follow\u2010up visit to report on their past\u2010month drinking. Baseline and follow\u2010up percent heavy drinking days (<jats:styled-content style=\"fixed-case\">PHDD<\/jats:styled-content>) were calculated for each participant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant effect of the brief intervention on <jats:styled-content style=\"fixed-case\">PHDD<\/jats:styled-content> at follow\u2010up or on modulating neural activation to alcohol relative to water taste cues. There was a significant association between neural response to alcohol taste cues and <jats:styled-content style=\"fixed-case\">PHDD<\/jats:styled-content> across groups (<jats:italic>Z<\/jats:italic>\u00a0&gt;\u00a02.3, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05), such that individuals who had greater neural reactivity to alcohol taste cues in the precuneus and prefrontal cortex (PFC) had fewer <jats:styled-content style=\"fixed-case\">PHDD<\/jats:styled-content> at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study did not find an effect of the brief intervention on alcohol use in this sample, and the intervention was not associated with differential neural alcohol cue reactivity. Nevertheless, greater activation of the precuneus and PFC during alcohol cue exposure predicted less alcohol use prospectively suggesting that these neural substrates subserve the effects of alcohol cues on drinking behavior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13941","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T14:04:14Z","timestamp":1545055454000},"page":"367-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elucidating the Effect of a Brief Drinking Intervention Using Neuroimaging: A Preliminary Study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-4918","authenticated-orcid":false,"given":"Erica N.","family":"Grodin","sequence":"first","affiliation":[{"name":"Department of Psychology University of California Los Angeles Los Angeles California"},{"name":"Department of Psychiatry and Biobehavioral Sciences UCLA School of Medicine University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-9444","authenticated-orcid":false,"given":"Lara A.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California Los Angeles Los Angeles California"},{"name":"Department of Psychiatry and Biobehavioral Sciences UCLA School of Medicine University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"MacKillop","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron C.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Psychology University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell P.","family":"Karno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences UCLA School of Medicine University of California Los Angeles Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.04.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2013.12071.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.2026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1300\/J465v28n04_01"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.68.4.728"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-012-0143-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.74.5.943"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsy010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.04.026"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agx037"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12437"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.01.007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1197\/aemj.9.6.627"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12960"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2005.66.369"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0031491"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2011.72.903"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01382.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029767"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.07.035"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301513"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00692.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04349.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/jama.1997.03540370029032","article-title":"Brief physician advice for problem alcohol drinkers\u2014a randomized controlled trial in community\u2010based primary care practices","volume":"277","author":"Fleming MF","year":"1997","journal-title":"J Am Med Assoc"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0546-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199910000-00003"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1828-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2002.63.551"},{"key":"e_1_2_7_31_1","first-page":"663","article-title":"A reduction in delay discounting by using episodic future imagination and the association with episodic memory capacity","volume":"10","author":"Hu X","year":"2016","journal-title":"Front Hum Neurosci"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12714"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.12.048"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01632.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2001.62.806"},{"key":"e_1_2_7_36_1","unstructured":"2002 The Guilford Press New York W Miller S Rollnick Motivational Interviewing: Preparing People for Change"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0016830"},{"key":"e_1_2_7_38_1","unstructured":"MoyersT(2004)The global rating of motivational interviewing therapists. Available at:http:\/\/casaa.unm.edu\/download\/GROMIT.pdf. Accessed May 21 2008."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28487-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-018-0749-y"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.064"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2015.01.001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-5-200303040-00006"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-3-200702060-00005"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2015.76.530"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2012.00464.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-2996-x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.762"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.03.016"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13112"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1988.tb00485.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1989.tb00737.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952990.2015.1136638"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.12.016"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12221"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13111495"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0027055"},{"key":"e_1_2_7_59_1","first-page":"251","article-title":"Statistical analysis of activation images","volume":"14","author":"Worsley K","year":"2001","journal-title":"Funct MRI"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0660-18.2018"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.023"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.07.019"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.13941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.13941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:07:01Z","timestamp":1694696821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.13941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,20]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/acer.13941"],"URL":"https:\/\/doi.org\/10.1111\/acer.13941","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,20]]},"assertion":[{"value":"2018-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}