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The goal of the current systematic review was to characterize the existing literature on this topic and to evaluate the credibility of <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> as a candidate pharmacotherapy for alcohol use disorder (<jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content>). Using a comprehensive search strategy, 303 unique potential articles were identified and 12 ultimately met criteria for inclusion (8 using rodent models, 3 using healthy adult volunteers, and 1 using cell culture). In both rodent and cell culture models, <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> was found to exert a neuroprotective effect against adverse alcohol consequences on the hippocampus. In rodent models, <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> was found to attenuate alcohol\u2010induced hepatotoxicity, specifically, alcohol\u2010induced steatosis. Finally, findings from preclinical rodent models also indicate that <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> attenuates cue\u2010elicited and stress\u2010elicited alcohol seeking, alcohol self\u2010administration, withdrawal\u2010induced convulsions, and impulsive discounting of delayed rewards. In human studies, <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> was well tolerated and did not interact with the subjective effects of alcohol. Collectively, given its favorable effects on alcohol\u2010related harms and addiction phenotypes in preclinical models, <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> appears to have promise as a candidate <jats:styled-content style=\"fixed-case\">AUD<\/jats:styled-content> pharmacotherapy. This is further bolstered by the absence of abuse liability and its general tolerability. A clear limitation to the literature is the paucity of human investigations. 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