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Here, we assessed the effectiveness of the dopamine\/norepinephrine re\u2010uptake inhibitor, bupropion (BUP<\/jats:styled-content>), alone and in combination with naltrexone (NAL<\/jats:styled-content>), to reduce binge\u2010like and chronic ethanol (EtOH) intake in mice. While BUP<\/jats:styled-content> is an FDA<\/jats:styled-content>\u2010approved drug that is currently used to treat depression and nicotine dependence, there has been only limited investigation to assess the ability of BUP<\/jats:styled-content> to reduce EtOH intake.<\/jats:p><\/jats:sec>Methods<\/jats:title>Male C57BL<\/jats:styled-content>\/6J mice were tested with 20% (v\/v) EtOH using \u201cdrinking in the dark\u201d (DID<\/jats:styled-content>) procedures to model binge\u2010like EtOH intake and following intermittent access to EtOH (IAE<\/jats:styled-content>). In Experiment 1, mice were given intraperitoneal (i.p.) injection of 0, 20, or 40\u00a0mg\/kg BUP<\/jats:styled-content> 30\u00a0minutes before DID<\/jats:styled-content> testing; in Experiment 2, mice were given i.p. injection of vehicle, BUP<\/jats:styled-content> (20\u00a0mg\/kg), NAL<\/jats:styled-content> (3\u00a0mg\/kg), or BUP<\/jats:styled-content>\u00a0+\u00a0NAL<\/jats:styled-content> (20 and 3\u00a0mg\/kg, respectively) 30\u00a0minutes before DID<\/jats:styled-content> testing; and in Experiment 3, mice were given i.p. injection of 0, 20, 40, or 60\u00a0mg\/kg BUP<\/jats:styled-content> 30\u00a0minutes before EtOH access after mice had 16\u00a0weeks of IAE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>BUP<\/jats:styled-content> dose dependently blunted EtOH intake with DID<\/jats:styled-content> procedures and after 16\u00a0weeks of IAE<\/jats:styled-content>. Administration of subthreshold doses of BUP<\/jats:styled-content>\u00a0+\u00a0NAL<\/jats:styled-content> also reduced binge\u2010like EtOH intake. Finally, BUP<\/jats:styled-content> failed to reduce consumption of a 3% (w\/v) sucrose solution.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>BUP<\/jats:styled-content>, alone and in combination with NAL<\/jats:styled-content>, may represent a novel approach to treating binge EtOH intake. We are currently assessing the efficacy of BUP<\/jats:styled-content> to curb binge drinking in a phase II<\/jats:styled-content> clinical trial experiment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.13992","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T16:00:15Z","timestamp":1551369615000},"page":"783-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Bupropion, Alone and in Combination with Naltrexone, Blunts Binge\u2010Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL<\/scp>\/6J Mice"],"prefix":"10.1111","volume":"43","author":[{"given":"Montserrat","family":"Navarro","sequence":"first","affiliation":[{"name":"Department of Psychology and Neuroscience University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"The Bowles Center for Alcohol Studies University of North Carolina at Chapel Hill Chapel Hill 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Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8908-9256","authenticated-orcid":false,"given":"Todd E.","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Psychology and Neuroscience University of North Carolina at Chapel Hill Chapel Hill North Carolina"},{"name":"The Bowles Center for Alcohol Studies University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"583","article-title":"Morphine down\u2010regulates melanocortin\u20104 receptor expression in brain regions that mediate opiate addiction","volume":"50","author":"Alvaro JD","year":"1996","journal-title":"Mol Pharmacol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.86"},{"key":"e_1_2_7_4_1","first-page":"395","article-title":"Bupropion: a 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