{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:31:41Z","timestamp":1760369501912,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Erythrocyte mean corpuscular volume (MCV) has been used for decades as a biomarker of chronic alcohol abuse and in the treatment of alcohol dependence. More recently, it has also been adopted to investigate the fitness of subjects to hold the driving license to prevent traffic accidents. So far, however, the studies on the association of <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> with an increased risk of alcohol\u2010associated car accidents are extremely scarce, if not totally absent. To the best of our knowledge, the present work is the first specifically aimed at studying a plausible association between elevated <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> and crash accidents correlated with alcohol abuse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 6,244 drivers involved in traffic accidents underwent mandatory laboratory analyses including blood alcohol concentration (<jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content>) determination and <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> analysis. <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> determinations were performed by headspace gas chromatography and complete blood count, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The chi\u2010square test evaluating the proportions of subjects with elevated <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>s (&gt;95\u00a0fl) yielded a highly significant result (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a068.0; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in the blood samples where the <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> was above the legal limit (i.e., &gt;0.5\u00a0g\/l). However, when considering only drivers showing <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content>s in the range of 0.51 to 1.5\u00a0g\/l, the frequencies of elevated <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> values are fairly comparable (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a00.062, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.80). In contrast, limiting the evaluation to <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content>s\u00a0&gt;\u00a01.5\u00a0g\/l, the frequency of elevated <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>s raised to 19.1% (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a058.9, <jats:italic>p<\/jats:italic> value\u00a0&lt;\u00a00.001 vs. the group with <jats:styled-content style=\"fixed-case\">BAC<\/jats:styled-content> within the legal limits).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present observations show that <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> increases are typically associated with drivers involved in accidents only if driving under severe alcohol intoxication, leading to a preliminary conclusion that, in the context of the certification of the fitness to the driving license, <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content> fails to reveal individuals at risk who tend to drive in a condition of low\u2010to\u2010moderate alcohol intoxication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14046","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T18:30:51Z","timestamp":1555353051000},"page":"1528-1532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Critical Evaluation of the Association Between Elevated Mean Corpuscular Volume and Alcohol\u2010Related Traffic Accidents: A Retrospective Study on 6244 Car Crash Cases"],"prefix":"10.1111","volume":"43","author":[{"given":"Nadia M.","family":"Porpiglia","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Public Health, Unit of Forensic Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-4585","authenticated-orcid":false,"given":"Federica","family":"Bortolotti","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Public Health, Unit of Forensic Medicine University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romolo M.","family":"Dorizzi","sequence":"additional","affiliation":[{"name":"U.O. 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