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Two promising strategies for treating AUD<\/jats:styled-content>s include cognitive bias modification (CBM<\/jats:styled-content>) and transcranial direct current stimulation (tDCS<\/jats:styled-content>). While each strategy has shown positive results in reducing drinking or alcohol\u2010related constructs (e.g., craving), initial tests of the combination of CBM<\/jats:styled-content> and tDCS<\/jats:styled-content> have shown mixed results. The present study investigated the degree to which combining CBM<\/jats:styled-content> and tDCS<\/jats:styled-content> (2.0 mA<\/jats:styled-content> anodal current over F10) could reduce alcohol approach biases and alcohol consumption.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010nine at\u2010risk drinkers were randomized to 1 of 4 conditions in a 2\u00a0\u00d7\u00a02 factorial design: verum CBM<\/jats:styled-content>\/verum tDCS<\/jats:styled-content>, verum CBM<\/jats:styled-content>\/sham tDCS<\/jats:styled-content>, sham CBM<\/jats:styled-content>\/verum tDCS<\/jats:styled-content>, or sham CBM<\/jats:styled-content>\/sham tDCS<\/jats:styled-content>. Participants completed a baseline assessment of alcohol approach bias and drinking quantity\/frequency (i.e., drinks per drinking day [DDD<\/jats:styled-content>] and percent heavy drinking days [PHDD<\/jats:styled-content>]), 4 sessions of combined CBM<\/jats:styled-content> and tDCS<\/jats:styled-content>, and follow\u2010up assessments of approach bias and alcohol consumption.<\/jats:p><\/jats:sec>Results<\/jats:title>Results indicated that while participants did demonstrate significant alcohol approach biases at baseline, neither CBM<\/jats:styled-content>, tDCS<\/jats:styled-content>, nor the interaction reduced the bias at the follow\u2010up. In addition, there was evidence of a trend toward reducing DDD<\/jats:styled-content> from baseline to the 1\u2010week\/1\u2010month follow\u2010ups, but there was no significant effect of the intervention on either DDD<\/jats:styled-content> or PHDD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These results partially replicated null results presented in similar CBM<\/jats:styled-content>\/tDCS<\/jats:styled-content> trials and suggest that this combination, at least with anodal stimulation over dorsolateral or inferior frontal sites, may have limited utility to reduce drinking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14111","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T12:50:38Z","timestamp":1557751838000},"page":"1591-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Randomized Trial of Combined tDCS<\/scp> Over Right Inferior Frontal Cortex and Cognitive Bias Modification: Null Effects on Drinking and Alcohol Approach Bias"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-0813","authenticated-orcid":false,"given":"Eric D.","family":"Claus","sequence":"first","affiliation":[{"name":"The Mind Research Network Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan D.","family":"Klimaj","sequence":"additional","affiliation":[{"name":"The Mind Research Network Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Chavez","sequence":"additional","affiliation":[{"name":"Center on Alcoholism, Substance Abuse, and Addiction University of New Mexico Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber D.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Center on Alcoholism, Substance Abuse, and Addiction University of New Mexico Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent P.","family":"Clark","sequence":"additional","affiliation":[{"name":"The Mind Research Network Albuquerque New Mexico"},{"name":"Psychology Clinical Neuroscience Center Department of Psychology University of New Mexico Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,31]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"1992 World Health Organization Geneva Switzerland T Babor J Fuente J Saunders M Grant The Alcohol Use Disorders Identification Test. 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