{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:56:30Z","timestamp":1786946190475,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["1P50AA022534\u201001"],"award-info":[{"award-number":["1P50AA022534\u201001"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["1R01AA025652\u201001"],"award-info":[{"award-number":["1R01AA025652\u201001"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["5T32AA014127e13"],"award-info":[{"award-number":["5T32AA014127e13"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fetal alcohol spectrum disorders (<jats:styled-content style=\"fixed-case\">FASD<\/jats:styled-content>) commonly include deficits in learning, memory, and executive control that can have a severe negative impact on quality of life across the life span. It is still unclear how prenatal alcohol exposure (<jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>) affects executive control processes, such as control over reward seeking, that lead to inappropriate behavior later in life. Learning and reinstatement of a previously learned response after extinction is a simple, well\u2010validated measure of both acquisition of a rewarded instrumental response and sensitivity to reward and reward\u2010associated cues. We investigated the effects of <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> on learning, extinction, and reinstatement of a simple instrumental response for food reward. Next, we assessed the effectiveness of an early intervention, communal nest (<jats:styled-content style=\"fixed-case\">CN<\/jats:styled-content>) housing, on increased reinstatement of an extinguished response seen after <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To assess the effects of <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> on control over reward seeking, we tested male and female <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> and saccharine (<jats:styled-content style=\"fixed-case\">SAC<\/jats:styled-content>) controls raised in a standard nest (<jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>) on the acquisition, extinction, and food reward\u2013induced reinstatement of an instrumental response utilizing a touch screen\u2010based paradigm. Next, in order to examine the effects of an early\u2010life intervention on these behaviors, we tested <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SAC<\/jats:styled-content> mice raised in a <jats:styled-content style=\"fixed-case\">CN<\/jats:styled-content> early\u2010life environment on these behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> mice readily acquired and extinguished a simple touch response to a white square stimulus. However, <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> mice showed significantly increased and persistent reinstatement compared to controls. Increased maternal care via rearing in <jats:styled-content style=\"fixed-case\">CN<\/jats:styled-content> slowed acquisition and sped extinction learning and rescued the significantly increased reinstatement responding in <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Together these results demonstrate that even moderate <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> is sufficient to alter control over reward seeking as measured by reinstatement. Importantly, an early\u2010life intervention previously shown to improve cognitive outcomes in <jats:styled-content style=\"fixed-case\">PAE<\/jats:styled-content> mice was sufficient to ameliorate this effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14149","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T19:23:05Z","timestamp":1563477785000},"page":"1949-1956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Increased Maternal Care Rescues Altered Reinstatement Responding Following Moderate Prenatal Alcohol Exposure"],"prefix":"10.1111","volume":"43","author":[{"given":"Sarah L.","family":"Olguin","sequence":"first","affiliation":[{"name":"Department of Neurosciences (SLO, AZ, AA, KCC, JLB) University of New Mexico School of Medicine Albuquerque New Mexico"},{"name":"New Mexico Alcohol Research Center (SLO, AA, KCC, JLB) UNM Health Sciences Center Albuquerque New 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C.","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (SLO, AZ, AA, KCC, JLB) University of New Mexico School of Medicine Albuquerque New Mexico"},{"name":"New Mexico Alcohol Research Center (SLO, AA, KCC, JLB) UNM Health Sciences Center Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-3263","authenticated-orcid":false,"given":"Jonathan L.","family":"Brigman","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (SLO, AZ, AA, KCC, JLB) University of New Mexico School of Medicine Albuquerque New Mexico"},{"name":"New Mexico Alcohol Research Center (SLO, AA, KCC, JLB) UNM Health Sciences Center Albuquerque New Mexico"},{"name":"Center for Brain Repair and Recovery (HZ, JLB) UNM Health Sciences Center Albuquerque New 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