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The adolescent intermittent ethanol (<jats:styled-content style=\"fixed-case\">AIE<\/jats:styled-content>) model developed by the <jats:styled-content style=\"fixed-case\">NADIA<\/jats:styled-content> consortium produces binge\u2010like Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> exposure episodes. The current experiment examined the effects of <jats:styled-content style=\"fixed-case\">AIE<\/jats:styled-content> on the reinforcing properties of Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> and genetic expression of cholinergic and dopaminergic factors within the posterior ventral tegmental area (<jats:styled-content style=\"fixed-case\">pVTA<\/jats:styled-content>) in Wistar male and female rats and in male alcohol\u2010preferring (P) rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats were exposed to the <jats:styled-content style=\"fixed-case\">AIE<\/jats:styled-content> or water during adolescence, and all testing occurred during adulthood. Wistar control and <jats:styled-content style=\"fixed-case\">AIE<\/jats:styled-content> rats were randomly assigned to groups that self\u2010administered 0 to 200\u00a0mg% Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>. Male P rats self\u2010administered 0 to 100\u00a0mg%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data indicated that exposure to <jats:styled-content style=\"fixed-case\">AIE<\/jats:styled-content> in both Wistar male and female rats (and male P rats) resulted in a significant leftward shift in dose\u2013response curve for Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> self\u2010administration into the <jats:styled-content style=\"fixed-case\">pVTA<\/jats:styled-content>. TaqMan array indicated that <jats:styled-content style=\"fixed-case\">AIE<\/jats:styled-content> exposure had divergent effects on the expression of nicotinic receptors (increased a7, reduction in a4 and a5). There were also sex\u2010specific effects of <jats:styled-content style=\"fixed-case\">AIE<\/jats:styled-content> on gene expression; male only reduction in D3 receptors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Binge\u2010like Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> exposure during adolescence enhances the sensitivity to the reinforcing properties of Et<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> during adulthood which could be part of biological sequelae that are the basis for the deleterious effects of adolescent alcohol consumption on the rate of alcoholism during adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14150","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T13:13:15Z","timestamp":1563801195000},"page":"1937-1948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Adolescent 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