{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:58Z","timestamp":1787013778230,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA023281"],"award-info":[{"award-number":["R01DA023281"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AA014351"],"award-info":[{"award-number":["R01AA014351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The nociceptin\/orphanin FQ opioid peptide (NOP) receptor and its endogenous ligand N\/OFQ have been implicated in the regulation of drug and alcohol use disorders (AUD). In particular, evidence demonstrated that NOP receptor activation blocks reinforcing and motivating effects of alcohol across a range of behavioral measures, including alcohol intake, conditioned place preference, and vulnerability to relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we show the effects of pharmacological activation and inhibition of NOP receptors on binge\u2010like alcohol consumption, as measured by the \u201cdrinking in the dark\u201d (DID) model in C57BL\/6J mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that 2 potent and selective NOP agonists AT\u2010202 (0, 0.3, 1, 3\u00a0mg\/kg) and AT\u2010312 (0, 0.3, 1\u00a0mg\/kg) did not affect binge alcohol drinking at doses that do not affect locomotor activity. AT\u2010202 also failed to alter DID behavior when administered to mice previously exposed to chronic alcohol treatment with an alcohol\u2010containing liquid diet. Conversely, treatment with either the high affinity NOP receptor antagonist SB\u2010612111 (0, 3, 10, 30\u00a0mg\/kg) or the selective antagonist LY2817412 (0, 3, 10, 30\u00a0mg\/kg) decreased binge drinking. SB\u2010612111 was effective at all doses examined, and LY2817412 was effective at 30\u00a0mg\/kg. Consistently, NOP receptor knockout mice consumed less alcohol compared to wild type. SB\u2010612111 reduced DID and increased sucrose consumption at doses that do not appear to affect locomotor activity. However, the high dose of SB\u2010612111 (30\u00a0mg\/kg) reduced alcohol intake but failed to inhibit preference in a 2\u2010bottle choice DID model that can assess moderate alcohol intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present results suggest that NOP receptor inhibition rather than activation may represent a valuable approach for treatment of AUD characterized by excessive alcohol consumption such as binge drinking.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.14165","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T09:06:32Z","timestamp":1565082392000},"page":"2167-2178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL\/6J Mice"],"prefix":"10.1111","volume":"43","author":[{"given":"Gloria","family":"Brunori","sequence":"first","affiliation":[{"name":"Department of Biomedical Science Charles E. 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