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We examined long\u2010term potentiation (LTP), long\u2010term depression (LTD), and depotentiation in the medial perforant path input to the dentate gyrus (DG) to determine the impact of PNEE on the dynamic range of bidirectional synaptic plasticity in both sexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PNEE reduced the responsiveness of the DGs of male but not in female offspring, and this effect was no longer apparent when GABAergic signaling was inhibited. There was also a sex\u2010specific LTD impairment in males, but increasing the duration of the conditioning stimulus could overcome this deficit. The magnitude of LTP was also reduced, but in both sexes following PNEE. This appears to be an increase in the threshold for induction, not in capacity, as the level of LTP induced in PNEE animals was increased to control levels when additional conditioning stimuli were administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data are the first to describe, in a single study, the impact of PNEE on the dynamic range of bidirectional synaptic plasticity in the juvenile DG in both males and in females. The data suggest that PNEE increases the threshold for LTP in the DG in both sexes, but produces a sex\u2010specific increase in the threshold for LTD in males These alterations reduce the dynamic range for synaptic plasticity in both sexes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14170","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T13:06:52Z","timestamp":1565096812000},"page":"2153-2166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impaired Bidirectional Synaptic Plasticity in Juvenile Offspring Following Prenatal Ethanol Exposure"],"prefix":"10.1111","volume":"43","author":[{"given":"Christine J.","family":"Fontaine","sequence":"first","affiliation":[{"name":"Division of Medical Sciences University of Victoria Victoria BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pinar","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences University of Victoria Victoria BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waisley","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences University of Victoria Victoria BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela F.","family":"Pang","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences University of Victoria Victoria BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad E.","family":"Suesser","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences University of Victoria Victoria BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S. 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