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We modeled the co\u2010use of alcohol and \u2206<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>) in adolescent mice using ingestive methods popular during this developmental period in humans, namely binge\u2010drinking and edible <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>. With this model, we assessed levels of use, acute effects, and tolerance to each substance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescent male C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6J mice had daily, limited access to 1 of 2 edible doughs (<jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> or control), to 1 of 2 fluids (ethanol (EtOH) or water), and in 1 of 2 orders (dough\u2013fluid or fluid\u2013dough). Home cage locomotor activity was recorded both during access and after access. On the day following the final access session, a subset of mice were assessed for functional and metabolic tolerance to alcohol using accelerating rotarod and blood EtOH concentrations, respectively. The remaining mice were assessed for tolerance to <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>\u2010induced hypothermia, and whole\u2010brain <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>1R expression was assessed in all mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EtOH intake was on par with levels previously reported in adolescent mice. Edible <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> was well\u2010consumed, but consumption decreased at the highest dose provided. Locomotor activity increased following EtOH intake and decreased following edible <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> consumption, and edible <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> increased fluid intake in general. The use of alcohol produced neither functional nor metabolic tolerance to an alcohol challenge. However, the use of edible <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> impaired subsequent drug\u2010free rotarod performance and was associated with a reduction in <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content>'s hypothermic effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescent mice self\u2010administered both alcohol and edible <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> to a degree sufficient to acutely impact locomotor activity. However, only edible <jats:styled-content style=\"fixed-case\">THC<\/jats:styled-content> consumption had lasting effects during short\u2010term abstinence. Thus, this adolescent co\u2010use model could be used to explore sex differences in self\u2010administration and the impact substance co\u2010use might have on other domains such as mood and cognition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14197","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T12:53:41Z","timestamp":1568638421000},"page":"2446-2457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of Acute Motor Effects and Tolerance Following Self\u2010Administration of Alcohol and Edible \u2206<sup>9<\/sup>\u2010Tetrahydrocannabinol in Adolescent Male Mice"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-7362","authenticated-orcid":false,"given":"Michael P.","family":"Smoker","sequence":"first","affiliation":[{"name":"From the Department of Psychology Indiana Alcohol Research Center Indiana University \u2013 Purdue 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