{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T02:46:40Z","timestamp":1779331600573,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T00:00:00Z","timestamp":1574553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Aldehyde dehydrogenase 2 (ALDH2) protects against alcohol\u2010evoked cardiac dysfunction in male rodents, but its role in the estrogen (E<jats:sub>2<\/jats:sub>)\u2010dependent hypersensitivity of female rats to alcohol\u2010evoked myocardial oxidative stress and dysfunction is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We addressed this question by studying the effect of cyanamide (ALDH2 inhibitor) on cardiac function, blood pressure, alcohol\u2010metabolizing enzyme (alcohol dehydrogenase, cytochrome P450 2E1, catalase, and ALDH2) activities, and cardiac redox status (reactive oxygen species, ROS; malondialdehyde, MDA) in the absence or presence of ethanol (EtOH) in female sham\u2010operated (SO) and ovariectomized (OVX) rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cyanamide attenuated the EtOH\u2010evoked myocardial dysfunction (reduced d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub> and LVDP) in SO rats. EtOH, cyanamide, or their combination did not alter d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub> or LVDP in OVX rats. Cyanamide induced cardiac oxidative stress and abrogated the subsequent alcohol\u2010evoked increases in ROS and MDA levels in SO rats. Neither EtOH nor cyanamide influenced ROS or MDA levels in OVX rats. Importantly, cyanamide exaggerated EtOH\u2010evoked hypotension in SO and uncovered this hypotensive response in OVX rats, which implicates ALDH2 in the vasodilating effect of EtOH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contrary to our hypothesis, cyanamide attenuated the E<jats:sub>2<\/jats:sub>\u2010dependent cardiac dysfunction caused by alcohol, likely by preconditioning the heart to oxidative stress, while exacerbating the vasodilating effect of alcohol. The latter might predispose to syncope when cyanamide and alcohol are combined in females.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14225","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T13:42:46Z","timestamp":1573047766000},"page":"45-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aldehyde Dehydrogenase Inhibition Ameliorates Cardiac Dysfunction and Exacerbates Hypotension Caused by Alcohol in Female Rats"],"prefix":"10.1111","volume":"44","author":[{"given":"Fanrong","family":"Yao","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology &amp; Toxicology Brody School of Medicine East Carolina University Greenville North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-2190","authenticated-orcid":false,"given":"Abdel 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