{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:47:06Z","timestamp":1791665226257,"version":"4.3.4"},"reference-count":131,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1111\/acer.14233","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T17:27:18Z","timestamp":1572974838000},"page":"23-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Five Priority Areas for Improving Medications Development for Alcohol Use Disorder and Promoting Their Routine Use in Clinical Practice"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7497-0809","authenticated-orcid":false,"given":"Raye Z.","family":"Litten","sequence":"first","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-2786","authenticated-orcid":false,"given":"Daniel E.","family":"Falk","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Ryan","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Fertig","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-8754","authenticated-orcid":false,"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse National Institutes of Health Bethesda Maryland"},{"name":"Medication Development Program National Institute on Drug Abuse National Institutes of Health Baltimore Maryland"},{"name":"Center for Alcohol and Addiction Studies Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61814-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30303-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.11.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.2.135"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13417"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12717"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.01.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.07.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/769639"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.105"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.01.021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2016.05.008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2017.0387"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13066"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/spc3.12121"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.113"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057110374993"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000246209.18777.14"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00291.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13556210500314550"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_85"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal3236"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000133"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.3079"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13917"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01290.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-4855-2"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.301"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12557"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v6.i1.66"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1431927616003548"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080999"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.03.016"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2019.1628218"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(17)30130-X"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.07.023"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_5006"},{"key":"e_1_2_10_39_1","first-page":"223A","article-title":"TSPANS, an alcohol responsive gene that alters serotonin levels in human induced pluripotent stem cells: novel molecular links to alcohol use disorder","volume":"43","author":"Ho MF","year":"2019","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"e_1_2_10_41_1","first-page":"751","article-title":"Screening out irrelevant cell\u2010based models of disease","volume":"15","author":"Horvath P","year":"2016","journal-title":"Nat Rev"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003142"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10548-009-0123-4"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/embj.201387098"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10050755"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12091163"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3628"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12643"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0811-16"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.02.015"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-012-1146-6"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12410"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.01.009"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13884"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2014.75.467"},{"key":"e_1_2_10_56_1","first-page":"1","article-title":"Concise review: drug discovery in the age of the induced pluripotent stem cell","volume":"4","author":"Ko HC","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.307"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010715-103143"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13081014"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000864"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6551"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.020"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.10.024"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.03.006"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132939"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0064-y"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.10.004"},{"key":"e_1_2_10_68_1","article-title":"Just-in-time but not too much: Determining treatment timing in mobile health","author":"Liao P","year":"2019","journal-title":"Proc ACM Interact Wearable Ubiquitous Technol"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.2217\/pme.11.7"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13222"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13093"},{"key":"e_1_2_10_72_1","first-page":"579","volume-title":"The Neuropharmacology of Alcohol: Handbook of Experimental Pharmacology","author":"Litten RZ","year":"2018"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01649.x"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12357"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12669"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0b013e31829623f4"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2015.1133472"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03601.x"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.282"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12546"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2003.tb00543.x"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-9616-1-17"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-018-0110-8"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12914"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.03.014"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2018.13"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14373"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v38.i2.30"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-1-201101040-00008"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417222112"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300219"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.3053"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2475"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3078"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.352.6288.877"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2018.03.004"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2018.03.017"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3940"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01704.x"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13147"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13811"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12725"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12747"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000508"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agv127"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MB00476H"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agz026"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.214"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.80"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605358113"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(01)00144-1"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.01.015"},{"issue":"20182803","key":"e_1_2_10_113_1","article-title":"Health care uses over 3 years after adolescent SBIRT","volume":"143","author":"Sterling S","year":"2019","journal-title":"Pediatrics"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.049"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000202"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(02)00319-7"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2017.1363238"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-02174-z"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000413"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-017-4202-z"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14018"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13272"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13897"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax4043"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14183"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12257"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.280377"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12349"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1338"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97924"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01532.x"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsads.2014.s17.79"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.14233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T04:44:07Z","timestamp":1694148247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.14233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,5]]},"references-count":131,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/acer.14233"],"URL":"https:\/\/doi.org\/10.1111\/acer.14233","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,5]]},"assertion":[{"value":"2019-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}